Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury, with MASP-2 playing a major role

The lectin pathway (LP) of complement activation is believed to contribute to brain inflammation. The study aims to identify the key components of the LP contributing to TBI outcome as possible novel pharmacological targets. We compared the long-term neurological deficits and neuropathology of wild-...

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Detalles Bibliográficos
Autores principales: Mercurio, D., Oggioni, M., Fumagalli, S., Lynch, N. J., Roscher, S., Minuta, D., Perego, C., Ippati, S., Wallis, R., Schwaeble, W. J., De Simoni, M.-G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592565/
https://www.ncbi.nlm.nih.gov/pubmed/33115535
http://dx.doi.org/10.1186/s40478-020-01041-1

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