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Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

BACKGROUND: Wnt signaling is a critical determinant for the maintenance and differentiation of stem/progenitor cells, including trophoblast stem cells during placental development. Hyperactivation of Wnt signaling has been shown to be associated with human trophoblast diseases. However, little is kn...

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Detalles Bibliográficos
Autores principales:	Bao, Haili, Liu, Dong, Xu, Yingchun, Sun, Yang, Mu, Change, Yu, Yongqin, Wang, Chunping, Han, Qian, Liu, Sanmei, Cai, Han, Liu, Fan, Kong, Shuangbo, Deng, Wenbo, Cao, Bin, Wang, Haibin, Wang, Qiang, Lu, Jinhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592576/ https://www.ncbi.nlm.nih.gov/pubmed/33109217 http://dx.doi.org/10.1186/s12915-020-00883-4

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