Efficacy of a novel double-controlled oncolytic adenovirus driven by the Ki67 core promoter and armed with IL-15 against glioblastoma cells

BACKGROUND: Glioblastoma (GBM) is an immunosuppressive, highly vascular and devastating malignant brain tumor. Even with progressive combination treatment that includes surgery, radiotherapy, and chemotherapy, the prognosis for GBM patients is still extremely poor. Oncolytic adenovirus (OAd) can spe...

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Detalles Bibliográficos
Autores principales: Zhang, Qing, Zhang, Junwen, Tian, Yifu, Zhu, Guidong, Liu, Sisi, Liu, Fusheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592588/
https://www.ncbi.nlm.nih.gov/pubmed/33133514
http://dx.doi.org/10.1186/s13578-020-00485-1

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