Mitochondrial DNA drives noncanonical inflammation activation via cGAS–STING signaling pathway in retinal microvascular endothelial cells

BACKGROUND: Pathological stimuli cause mitochondrial damage and leakage of mitochondrial DNA (mtDNA) into the cytosol, as demonstrated in many cell types. The cytosolic mtDNA then drives the activation of noninfectious inflammation. Retinal microvascular endothelial cells (RMECs) play an important r...

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Detalles Bibliográficos
Autores principales: Guo, Yue, Gu, Ruiping, Gan, Dekang, Hu, Fangyuan, Li, Gang, Xu, Gezhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592595/
https://www.ncbi.nlm.nih.gov/pubmed/33115500
http://dx.doi.org/10.1186/s12964-020-00637-3

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