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Mitochondrial DNA drives noncanonical inflammation activation via cGAS–STING signaling pathway in retinal microvascular endothelial cells
BACKGROUND: Pathological stimuli cause mitochondrial damage and leakage of mitochondrial DNA (mtDNA) into the cytosol, as demonstrated in many cell types. The cytosolic mtDNA then drives the activation of noninfectious inflammation. Retinal microvascular endothelial cells (RMECs) play an important r...
Autores principales: | Guo, Yue, Gu, Ruiping, Gan, Dekang, Hu, Fangyuan, Li, Gang, Xu, Gezhi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592595/ https://www.ncbi.nlm.nih.gov/pubmed/33115500 http://dx.doi.org/10.1186/s12964-020-00637-3 |
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