Potentially Pathogenic Calcium Oxalate Dihydrate and Titanium Dioxide Crystals in the Alzheimer’s Disease Entorhinal Cortex

Knowing that Alzheimer’s disease (AD) nucleates in the entorhinal cortex (EC), samples of 12 EC specimens were probed for crystals by a protocol detecting fewer than 1/5000th of those present. Of the 61 crystals found, 31 were expected and 30 were novel. Twenty-one crystals of iron oxides and 10 ath...

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Detalles Bibliográficos
Autores principales: Heller, Adam, Coffman, Sheryl S., Jarvis, Karalee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592648/
https://www.ncbi.nlm.nih.gov/pubmed/32804151
http://dx.doi.org/10.3233/JAD-200535
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author Heller, Adam
Coffman, Sheryl S.
Jarvis, Karalee
author_facet Heller, Adam
Coffman, Sheryl S.
Jarvis, Karalee
author_sort Heller, Adam
collection PubMed
description Knowing that Alzheimer’s disease (AD) nucleates in the entorhinal cortex (EC), samples of 12 EC specimens were probed for crystals by a protocol detecting fewer than 1/5000th of those present. Of the 61 crystals found, 31 were expected and 30 were novel. Twenty-one crystals of iron oxides and 10 atherosclerosis-associated calcium pyrophosphate dihydrate crystals were expected and found. The 30 unexpected crystals were NLRP3-inflammasome activating calcium oxalate dihydrate (12) and titanium dioxide (18). Their unusual distribution raises the possibility that some were of AD origination sites.
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spelling pubmed-75926482020-10-30 Potentially Pathogenic Calcium Oxalate Dihydrate and Titanium Dioxide Crystals in the Alzheimer’s Disease Entorhinal Cortex Heller, Adam Coffman, Sheryl S. Jarvis, Karalee J Alzheimers Dis Short Communication Knowing that Alzheimer’s disease (AD) nucleates in the entorhinal cortex (EC), samples of 12 EC specimens were probed for crystals by a protocol detecting fewer than 1/5000th of those present. Of the 61 crystals found, 31 were expected and 30 were novel. Twenty-one crystals of iron oxides and 10 atherosclerosis-associated calcium pyrophosphate dihydrate crystals were expected and found. The 30 unexpected crystals were NLRP3-inflammasome activating calcium oxalate dihydrate (12) and titanium dioxide (18). Their unusual distribution raises the possibility that some were of AD origination sites. IOS Press 2020-09-15 /pmc/articles/PMC7592648/ /pubmed/32804151 http://dx.doi.org/10.3233/JAD-200535 Text en © 2020 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Heller, Adam
Coffman, Sheryl S.
Jarvis, Karalee
Potentially Pathogenic Calcium Oxalate Dihydrate and Titanium Dioxide Crystals in the Alzheimer’s Disease Entorhinal Cortex
title Potentially Pathogenic Calcium Oxalate Dihydrate and Titanium Dioxide Crystals in the Alzheimer’s Disease Entorhinal Cortex
title_full Potentially Pathogenic Calcium Oxalate Dihydrate and Titanium Dioxide Crystals in the Alzheimer’s Disease Entorhinal Cortex
title_fullStr Potentially Pathogenic Calcium Oxalate Dihydrate and Titanium Dioxide Crystals in the Alzheimer’s Disease Entorhinal Cortex
title_full_unstemmed Potentially Pathogenic Calcium Oxalate Dihydrate and Titanium Dioxide Crystals in the Alzheimer’s Disease Entorhinal Cortex
title_short Potentially Pathogenic Calcium Oxalate Dihydrate and Titanium Dioxide Crystals in the Alzheimer’s Disease Entorhinal Cortex
title_sort potentially pathogenic calcium oxalate dihydrate and titanium dioxide crystals in the alzheimer’s disease entorhinal cortex
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592648/
https://www.ncbi.nlm.nih.gov/pubmed/32804151
http://dx.doi.org/10.3233/JAD-200535
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