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Early-Onset Familial Alzheimer Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype

BACKGROUND: Early-onset familial Alzheimer disease (EOFAD) is caused by heterozygous variants in the presenilin 1 (PSEN1), presenilin 2 (PSEN2), and APP genes. Decades after their discovery, the mechanisms by which these genes cause Alzheimer’s disease (AD) or promote AD progression are not fully un...

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Detalles Bibliográficos
Autores principales:	Fung, Susan, Smith, Carole L., Prater, Katherine E., Case, Amanda, Green, Kevin, Osnis, Leah, Winston, Chloe, Kinoshita, Yoshito, Sopher, Bryce, Morrison, Richard S., Garden, Gwenn A., Jayadev, Suman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592656/ https://www.ncbi.nlm.nih.gov/pubmed/32741831 http://dx.doi.org/10.3233/JAD-200492

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