Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2

Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations may provide some protection against SARS-CoV-2...

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Detalles Bibliográficos
Autores principales: Kandeil, Ahmed, Gomaa, Mokhtar R., El Taweel, Ahmed, Mostafa, Ahmed, Shehata, Mahmoud, Kayed, Ahmed E., Kutkat, Omnia, Moatasim, Yassmin, Mahmoud, Sara H., Kamel, Mina Nabil, Shama, Noura M. Abo, El Sayes, Mohamed, El-Shesheny, Rabeh, Yassien, Mahmoud A., Webby, Richard J., Kayali, Ghazi, Ali, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592750/
https://www.ncbi.nlm.nih.gov/pubmed/33112930
http://dx.doi.org/10.1371/journal.pone.0241471
Descripción
Sumario:Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations may provide some protection against SARS-CoV-2 infection through trained or adaptive immune responses. Here, we tested whether BCG, Pneumococcal, Rotavirus, Diphtheria, Tetanus, Pertussis, Hepatitis B, Haemophilus influenzae, Hepatitis B, Meningococcal, Measles, Mumps, and Rubella vaccines provide cross-reactive neutralizing antibodies against SARS-CoV-2 in BALB/c mice. Results indicated that none of these vaccines provided antibodies capable of neutralizing SARS-CoV-2 up to seven weeks post vaccination. We conclude that if such vaccines have any role in COVID-19 immunity, this role is not antibody-mediated.

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