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Precancerous lesions of the cervix and its determinants among Ethiopian women: Systematic review and meta-analysis

INTRODUCTION: Precancerous lesions of the cervix are changes in cervical cells that make them more likely to develop into cancer. Understanding the prevalence and determinants of the precancerous lesions of the cervix among women helps to take an action like vaccination programs, improving screening...

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Autores principales: Tsehay, Binalfew, Afework, Mekbeb
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592780/
https://www.ncbi.nlm.nih.gov/pubmed/33112875
http://dx.doi.org/10.1371/journal.pone.0240353
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author Tsehay, Binalfew
Afework, Mekbeb
author_facet Tsehay, Binalfew
Afework, Mekbeb
author_sort Tsehay, Binalfew
collection PubMed
description INTRODUCTION: Precancerous lesions of the cervix are changes in cervical cells that make them more likely to develop into cancer. Understanding the prevalence and determinants of the precancerous lesions of the cervix among women helps to take an action like vaccination programs, improving screening coverage, and close management and follow-up which could decrease the morbidity and mortality caused by cervical cancer. MATERIALS AND METHODS: The international databases, PubMed/MEDLINE, Web of Science, EMBASE, CINAHL, Google Scholar, Science Direct and Cochrane Library and unpublished reports were systematically searched. Two authors independently extracted all necessary data using a standardized data extraction format. STATA 14 statistical software was employed to analyse the data. The Cochrane Q test statistics and I(2) tests were used to assess the heterogeneity between the studies. A random-effect model was computed to estimate the pooled prevalence of precancerous lesions of the cervix in Ethiopia. Determinants of the precancerous lesion of cervix (early initiation of sexual intercourse, multiple sexual partners, and history of sexually transmitted infection) were analysed. RESULTS: Thirteen studies fulfilled the inclusion criteria and included in the meta-analysis. The I(2) test result showed high heterogeneity (I2, 93.2%, p = <0.001). Using the random effect analysis, the pooled prevalence of precancerous lesions of the cervix among women in Ethiopia was 14.21% (95% CI (10.49, 17.94). After adjusting of publication bias using trim-and-fill method, the pooled prevalence was 9.43% (95% CI (5.23, 13.62). Women who had multiple sexual partners in their lifetime (OR:2.67 CI: 1.49,4.79) and had a history of sexually transmitted infections (OR:6.22 CI: 2.99,12.92) were more likely to have a precancerous lesion of the cervix. CONCLUSION: The pooled prevalence of the precancerous lesions of the cervix among Ethiopian women was 9.43%. It was associated with having multiple sexual partners and a history of sexually transmitted infections.
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spelling pubmed-75927802020-11-02 Precancerous lesions of the cervix and its determinants among Ethiopian women: Systematic review and meta-analysis Tsehay, Binalfew Afework, Mekbeb PLoS One Research Article INTRODUCTION: Precancerous lesions of the cervix are changes in cervical cells that make them more likely to develop into cancer. Understanding the prevalence and determinants of the precancerous lesions of the cervix among women helps to take an action like vaccination programs, improving screening coverage, and close management and follow-up which could decrease the morbidity and mortality caused by cervical cancer. MATERIALS AND METHODS: The international databases, PubMed/MEDLINE, Web of Science, EMBASE, CINAHL, Google Scholar, Science Direct and Cochrane Library and unpublished reports were systematically searched. Two authors independently extracted all necessary data using a standardized data extraction format. STATA 14 statistical software was employed to analyse the data. The Cochrane Q test statistics and I(2) tests were used to assess the heterogeneity between the studies. A random-effect model was computed to estimate the pooled prevalence of precancerous lesions of the cervix in Ethiopia. Determinants of the precancerous lesion of cervix (early initiation of sexual intercourse, multiple sexual partners, and history of sexually transmitted infection) were analysed. RESULTS: Thirteen studies fulfilled the inclusion criteria and included in the meta-analysis. The I(2) test result showed high heterogeneity (I2, 93.2%, p = <0.001). Using the random effect analysis, the pooled prevalence of precancerous lesions of the cervix among women in Ethiopia was 14.21% (95% CI (10.49, 17.94). After adjusting of publication bias using trim-and-fill method, the pooled prevalence was 9.43% (95% CI (5.23, 13.62). Women who had multiple sexual partners in their lifetime (OR:2.67 CI: 1.49,4.79) and had a history of sexually transmitted infections (OR:6.22 CI: 2.99,12.92) were more likely to have a precancerous lesion of the cervix. CONCLUSION: The pooled prevalence of the precancerous lesions of the cervix among Ethiopian women was 9.43%. It was associated with having multiple sexual partners and a history of sexually transmitted infections. Public Library of Science 2020-10-28 /pmc/articles/PMC7592780/ /pubmed/33112875 http://dx.doi.org/10.1371/journal.pone.0240353 Text en © 2020 Tsehay, Afework http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tsehay, Binalfew
Afework, Mekbeb
Precancerous lesions of the cervix and its determinants among Ethiopian women: Systematic review and meta-analysis
title Precancerous lesions of the cervix and its determinants among Ethiopian women: Systematic review and meta-analysis
title_full Precancerous lesions of the cervix and its determinants among Ethiopian women: Systematic review and meta-analysis
title_fullStr Precancerous lesions of the cervix and its determinants among Ethiopian women: Systematic review and meta-analysis
title_full_unstemmed Precancerous lesions of the cervix and its determinants among Ethiopian women: Systematic review and meta-analysis
title_short Precancerous lesions of the cervix and its determinants among Ethiopian women: Systematic review and meta-analysis
title_sort precancerous lesions of the cervix and its determinants among ethiopian women: systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592780/
https://www.ncbi.nlm.nih.gov/pubmed/33112875
http://dx.doi.org/10.1371/journal.pone.0240353
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