Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function

Ciliary microtubules are subject to post-translational modifications that act as a “Tubulin Code” to regulate motor traffic, binding proteins and stability. In humans, loss of CCP1, a cytosolic carboxypeptidase and tubulin deglutamylating enzyme, causes infantile-onset neurodegeneration. In C. elega...

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Detalles Bibliográficos
Autores principales: Power, Kade M., Akella, Jyothi S., Gu, Amanda, Walsh, Jonathon D., Bellotti, Sebastian, Morash, Margaret, Zhang, Winnie, Ramadan, Yasmin H., Ross, Nicole, Golden, Andy, Smith, Harold E., Barr, Maureen M., O’Hagan, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592914/
https://www.ncbi.nlm.nih.gov/pubmed/33064774
http://dx.doi.org/10.1371/journal.pgen.1009052

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