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Clinical characteristics of patients with uremia undergoing maintenance hemodialysis complicated with COVID-19

This study aimed to evaluate the onset characteristics of patients with uremia undergoing maintenance hemodialysis complicated with COVID-19, so as to improve the understanding, diagnosis, and treatment. 26 cases were confirmed cases of COVID-19. Confirmed patients with COVID-19 undergoing maintenan...

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Autores principales: Wang, You, Hu, Manli, Ye, Gang, Zhao, Yuanyuan, Yin, Qingqiao, Pi, Pei, Luo, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593003/
https://www.ncbi.nlm.nih.gov/pubmed/32769892
http://dx.doi.org/10.1097/MD.0000000000021547
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author Wang, You
Hu, Manli
Ye, Gang
Zhao, Yuanyuan
Yin, Qingqiao
Pi, Pei
Luo, Dan
author_facet Wang, You
Hu, Manli
Ye, Gang
Zhao, Yuanyuan
Yin, Qingqiao
Pi, Pei
Luo, Dan
author_sort Wang, You
collection PubMed
description This study aimed to evaluate the onset characteristics of patients with uremia undergoing maintenance hemodialysis complicated with COVID-19, so as to improve the understanding, diagnosis, and treatment. 26 cases were confirmed cases of COVID-19. Confirmed patients with COVID-19 undergoing maintenance hemodialysis in the blood purification center were recruited. The general data of patients, including age, sex, duration of dialysis, and basic diseases, were analyzed. The clinical features included fever, respiratory symptoms, and gastrointestinal symptoms. The items for laboratory tests included blood routine examination, liver function, C-reactive protein, procalcitonin, creatine kinase, creatine kinase-MB, markers of myocardial injury, B-type natriuretic peptide, D-dimer, and so forth. The imaging examinations referred mainly to computed tomography imaging findings of the lungs. Twenty-one cases were complicated with chronic basic diseases, such as hypertension or diabetes. In terms of clinical manifestations, 13 cases had fever, which was close to the number of cases without fever (13 cases). The respiratory symptoms included dry cough (19 cases), shortness of breath (9 cases), fatigue (11 cases), and so forth. Further, 15 patients had hypoxemia, indicating more severe patients. Sore throat (2 cases) was not significant, and a few patients reported gastrointestinal symptoms (3 cases). The results of blood routine examination showed decreased absolute lymphocyte count (0.7 ± 0.4 × 10∼9/L), lower hemoglobin level (105.2 ± 20 g/L), and normal absolute neutrophil count 4.2 (3.0, 5.9) × 10∼9/L. Of the inflammatory indexes, procalcitonin was 0.69 (0.24, 2.73) ng/mL; C reactive protein was 17.2 (5.2, 181.6) mg/L, which was higher than normal. Blood biochemistry revealed lower albumin level (38.0 ± 4.0 g/L) and higher troponin 0.11(0.035, 6.658) ng/mL and myoglobin levels (538.5 ± 240.5 ng/mL), suggesting myocardial injury. The patients with uremia and confirmed COVID-19 undergoing maintenance hemodialysis are more common in males. Although the proportion of fever patients is 50%, the proportion of hypoxemia patients is high (58%). With poor cardiac function. They were prone to respiratory failure complicated with heart failure. According to the onset characteristics of this population, early diagnosis and treatment could help reduce the risk of developing a critical illness and control the spread of the COVID-19 epidemic.
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spelling pubmed-75930032020-10-29 Clinical characteristics of patients with uremia undergoing maintenance hemodialysis complicated with COVID-19 Wang, You Hu, Manli Ye, Gang Zhao, Yuanyuan Yin, Qingqiao Pi, Pei Luo, Dan Medicine (Baltimore) 7300 This study aimed to evaluate the onset characteristics of patients with uremia undergoing maintenance hemodialysis complicated with COVID-19, so as to improve the understanding, diagnosis, and treatment. 26 cases were confirmed cases of COVID-19. Confirmed patients with COVID-19 undergoing maintenance hemodialysis in the blood purification center were recruited. The general data of patients, including age, sex, duration of dialysis, and basic diseases, were analyzed. The clinical features included fever, respiratory symptoms, and gastrointestinal symptoms. The items for laboratory tests included blood routine examination, liver function, C-reactive protein, procalcitonin, creatine kinase, creatine kinase-MB, markers of myocardial injury, B-type natriuretic peptide, D-dimer, and so forth. The imaging examinations referred mainly to computed tomography imaging findings of the lungs. Twenty-one cases were complicated with chronic basic diseases, such as hypertension or diabetes. In terms of clinical manifestations, 13 cases had fever, which was close to the number of cases without fever (13 cases). The respiratory symptoms included dry cough (19 cases), shortness of breath (9 cases), fatigue (11 cases), and so forth. Further, 15 patients had hypoxemia, indicating more severe patients. Sore throat (2 cases) was not significant, and a few patients reported gastrointestinal symptoms (3 cases). The results of blood routine examination showed decreased absolute lymphocyte count (0.7 ± 0.4 × 10∼9/L), lower hemoglobin level (105.2 ± 20 g/L), and normal absolute neutrophil count 4.2 (3.0, 5.9) × 10∼9/L. Of the inflammatory indexes, procalcitonin was 0.69 (0.24, 2.73) ng/mL; C reactive protein was 17.2 (5.2, 181.6) mg/L, which was higher than normal. Blood biochemistry revealed lower albumin level (38.0 ± 4.0 g/L) and higher troponin 0.11(0.035, 6.658) ng/mL and myoglobin levels (538.5 ± 240.5 ng/mL), suggesting myocardial injury. The patients with uremia and confirmed COVID-19 undergoing maintenance hemodialysis are more common in males. Although the proportion of fever patients is 50%, the proportion of hypoxemia patients is high (58%). With poor cardiac function. They were prone to respiratory failure complicated with heart failure. According to the onset characteristics of this population, early diagnosis and treatment could help reduce the risk of developing a critical illness and control the spread of the COVID-19 epidemic. Wolters Kluwer Health 2020-08-07 /pmc/articles/PMC7593003/ /pubmed/32769892 http://dx.doi.org/10.1097/MD.0000000000021547 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 7300
Wang, You
Hu, Manli
Ye, Gang
Zhao, Yuanyuan
Yin, Qingqiao
Pi, Pei
Luo, Dan
Clinical characteristics of patients with uremia undergoing maintenance hemodialysis complicated with COVID-19
title Clinical characteristics of patients with uremia undergoing maintenance hemodialysis complicated with COVID-19
title_full Clinical characteristics of patients with uremia undergoing maintenance hemodialysis complicated with COVID-19
title_fullStr Clinical characteristics of patients with uremia undergoing maintenance hemodialysis complicated with COVID-19
title_full_unstemmed Clinical characteristics of patients with uremia undergoing maintenance hemodialysis complicated with COVID-19
title_short Clinical characteristics of patients with uremia undergoing maintenance hemodialysis complicated with COVID-19
title_sort clinical characteristics of patients with uremia undergoing maintenance hemodialysis complicated with covid-19
topic 7300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593003/
https://www.ncbi.nlm.nih.gov/pubmed/32769892
http://dx.doi.org/10.1097/MD.0000000000021547
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