Cargando…

Primary Sjögren syndrome-associated acute interstitial nephritis and type 3 renal tubular acidosis in a patient with thin basement membrane nephropathy: A case report

INTRODUCTION: The kidney is one of the common extraglandular sites involved in primary Sjögren syndrome (pSS), with chronic tubulointerstitial nephritis (TIN) the most common pathology type. Renal involvement in pSS often presents as chronic TIN accompanied by type 1 or 2 renal tubular acidosis (RTA...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Tian, Liu, Xiaohang, Ye, Wei, Ye, Wenling, Li, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593052/
https://www.ncbi.nlm.nih.gov/pubmed/32769933
http://dx.doi.org/10.1097/MD.0000000000021644
_version_ 1783601297850630144
author Du, Tian
Liu, Xiaohang
Ye, Wei
Ye, Wenling
Li, Chao
author_facet Du, Tian
Liu, Xiaohang
Ye, Wei
Ye, Wenling
Li, Chao
author_sort Du, Tian
collection PubMed
description INTRODUCTION: The kidney is one of the common extraglandular sites involved in primary Sjögren syndrome (pSS), with chronic tubulointerstitial nephritis (TIN) the most common pathology type. Renal involvement in pSS often presents as chronic TIN accompanied by type 1 or 2 renal tubular acidosis (RTA). Description of renal involvement as acute TIN with type III RTA in pSS has been rarely reported. PATIENT CONCERNS: A 37-year-old woman was admitted with complaints of dry mouth, dry eyes, and progressive muscle weakness for 17 months. Two months before admission, the patient had a blood potassium level of 1.7 mmol/L. DIAGNOSIS: Further tests confirmed pSS and type III RTA. Renal biopsy demonstrated acute TIN and thin basement membrane nephropathy (TBMN). INTERVENTIONS: Full-dose corticosteroid (1 mg/kg/day) and cyclophosphamide (100 mg/day) were applied. OUTCOMES: The creatinine levels of the patient decreased 0.28 mg/dL (1.18–0.90 mg/dL) during 3-month follow-up. CONCLUSIONS: We reported a patient with pSS-associated kidney injury, presenting as acute TIN with type 3 RTA and TBMN. This case increases the awareness of a rare manifestation of pSS-associated kidney injury. In pSS-associated acute TIN, cyclophosphamide combined with full-dose corticosteroids may achieve good outcomes.
format Online
Article
Text
id pubmed-7593052
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-75930522020-10-29 Primary Sjögren syndrome-associated acute interstitial nephritis and type 3 renal tubular acidosis in a patient with thin basement membrane nephropathy: A case report Du, Tian Liu, Xiaohang Ye, Wei Ye, Wenling Li, Chao Medicine (Baltimore) 5200 INTRODUCTION: The kidney is one of the common extraglandular sites involved in primary Sjögren syndrome (pSS), with chronic tubulointerstitial nephritis (TIN) the most common pathology type. Renal involvement in pSS often presents as chronic TIN accompanied by type 1 or 2 renal tubular acidosis (RTA). Description of renal involvement as acute TIN with type III RTA in pSS has been rarely reported. PATIENT CONCERNS: A 37-year-old woman was admitted with complaints of dry mouth, dry eyes, and progressive muscle weakness for 17 months. Two months before admission, the patient had a blood potassium level of 1.7 mmol/L. DIAGNOSIS: Further tests confirmed pSS and type III RTA. Renal biopsy demonstrated acute TIN and thin basement membrane nephropathy (TBMN). INTERVENTIONS: Full-dose corticosteroid (1 mg/kg/day) and cyclophosphamide (100 mg/day) were applied. OUTCOMES: The creatinine levels of the patient decreased 0.28 mg/dL (1.18–0.90 mg/dL) during 3-month follow-up. CONCLUSIONS: We reported a patient with pSS-associated kidney injury, presenting as acute TIN with type 3 RTA and TBMN. This case increases the awareness of a rare manifestation of pSS-associated kidney injury. In pSS-associated acute TIN, cyclophosphamide combined with full-dose corticosteroids may achieve good outcomes. Wolters Kluwer Health 2020-08-07 /pmc/articles/PMC7593052/ /pubmed/32769933 http://dx.doi.org/10.1097/MD.0000000000021644 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5200
Du, Tian
Liu, Xiaohang
Ye, Wei
Ye, Wenling
Li, Chao
Primary Sjögren syndrome-associated acute interstitial nephritis and type 3 renal tubular acidosis in a patient with thin basement membrane nephropathy: A case report
title Primary Sjögren syndrome-associated acute interstitial nephritis and type 3 renal tubular acidosis in a patient with thin basement membrane nephropathy: A case report
title_full Primary Sjögren syndrome-associated acute interstitial nephritis and type 3 renal tubular acidosis in a patient with thin basement membrane nephropathy: A case report
title_fullStr Primary Sjögren syndrome-associated acute interstitial nephritis and type 3 renal tubular acidosis in a patient with thin basement membrane nephropathy: A case report
title_full_unstemmed Primary Sjögren syndrome-associated acute interstitial nephritis and type 3 renal tubular acidosis in a patient with thin basement membrane nephropathy: A case report
title_short Primary Sjögren syndrome-associated acute interstitial nephritis and type 3 renal tubular acidosis in a patient with thin basement membrane nephropathy: A case report
title_sort primary sjögren syndrome-associated acute interstitial nephritis and type 3 renal tubular acidosis in a patient with thin basement membrane nephropathy: a case report
topic 5200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593052/
https://www.ncbi.nlm.nih.gov/pubmed/32769933
http://dx.doi.org/10.1097/MD.0000000000021644
work_keys_str_mv AT dutian primarysjogrensyndromeassociatedacuteinterstitialnephritisandtype3renaltubularacidosisinapatientwiththinbasementmembranenephropathyacasereport
AT liuxiaohang primarysjogrensyndromeassociatedacuteinterstitialnephritisandtype3renaltubularacidosisinapatientwiththinbasementmembranenephropathyacasereport
AT yewei primarysjogrensyndromeassociatedacuteinterstitialnephritisandtype3renaltubularacidosisinapatientwiththinbasementmembranenephropathyacasereport
AT yewenling primarysjogrensyndromeassociatedacuteinterstitialnephritisandtype3renaltubularacidosisinapatientwiththinbasementmembranenephropathyacasereport
AT lichao primarysjogrensyndromeassociatedacuteinterstitialnephritisandtype3renaltubularacidosisinapatientwiththinbasementmembranenephropathyacasereport