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Heterogeneity of T3 stage esophageal squamous cell carcinoma in different parts based on enhanced CT radiomics
Esophageal cancer is a common malignant tumor of the digestive system with a high incidence and a poor prognosis. At the present, CT-based radiomics is providing more and more valuable information. However, the heterogeneity of the study and the poor repeatability of the texture feature parameters h...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593053/ https://www.ncbi.nlm.nih.gov/pubmed/32769880 http://dx.doi.org/10.1097/MD.0000000000021470 |
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author | Li, Xiao-feng Wang, Qiang Duan, Shao-feng Yao, Biao Liu, Cai-yun |
author_facet | Li, Xiao-feng Wang, Qiang Duan, Shao-feng Yao, Biao Liu, Cai-yun |
author_sort | Li, Xiao-feng |
collection | PubMed |
description | Esophageal cancer is a common malignant tumor of the digestive system with a high incidence and a poor prognosis. At the present, CT-based radiomics is providing more and more valuable information. However, the heterogeneity of the study and the poor repeatability of the texture feature parameters have limited its wider clinical application. In the present study, we focused on comparing the differences in the texture features of T3 stage esophageal squamous cell carcinoma at different locations and normal esophageal wall, aiming to provide some pieces of useful information for future research on esophageal squamous cell carcinoma. Fifty seven cases with throat CT imaging, including esophageal cancer contrast enhanced CT and conventional CT of healthy control group. The texture characteristics in control group and tumor group among different parts were compared. Using Univariable analysis, we compared the difference and conducted receiver-operator curve analysis to evaluate the performance of tumor grade diagnosis model. 53 radiomic features were significantly different in control group and so as 93 features for tumor group. The upper section was the mostly different from the other 2 sections. Run-length matrix (RLM) features in tumor group accounted for the highest proportion, only Surface Volume Ratio was different. There are differences in the texture features of the tube wall in different parts of the esophagus of healthy adults, and this difference is more obvious in pT3 stage esophageal squamous cell carcinoma. In the future radiomics study of esophageal squamous cell carcinoma, we need to pay attention to this to avoid affecting the accuracy of the results. |
format | Online Article Text |
id | pubmed-7593053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-75930532020-10-29 Heterogeneity of T3 stage esophageal squamous cell carcinoma in different parts based on enhanced CT radiomics Li, Xiao-feng Wang, Qiang Duan, Shao-feng Yao, Biao Liu, Cai-yun Medicine (Baltimore) 6800 Esophageal cancer is a common malignant tumor of the digestive system with a high incidence and a poor prognosis. At the present, CT-based radiomics is providing more and more valuable information. However, the heterogeneity of the study and the poor repeatability of the texture feature parameters have limited its wider clinical application. In the present study, we focused on comparing the differences in the texture features of T3 stage esophageal squamous cell carcinoma at different locations and normal esophageal wall, aiming to provide some pieces of useful information for future research on esophageal squamous cell carcinoma. Fifty seven cases with throat CT imaging, including esophageal cancer contrast enhanced CT and conventional CT of healthy control group. The texture characteristics in control group and tumor group among different parts were compared. Using Univariable analysis, we compared the difference and conducted receiver-operator curve analysis to evaluate the performance of tumor grade diagnosis model. 53 radiomic features were significantly different in control group and so as 93 features for tumor group. The upper section was the mostly different from the other 2 sections. Run-length matrix (RLM) features in tumor group accounted for the highest proportion, only Surface Volume Ratio was different. There are differences in the texture features of the tube wall in different parts of the esophagus of healthy adults, and this difference is more obvious in pT3 stage esophageal squamous cell carcinoma. In the future radiomics study of esophageal squamous cell carcinoma, we need to pay attention to this to avoid affecting the accuracy of the results. Wolters Kluwer Health 2020-08-07 /pmc/articles/PMC7593053/ /pubmed/32769880 http://dx.doi.org/10.1097/MD.0000000000021470 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 6800 Li, Xiao-feng Wang, Qiang Duan, Shao-feng Yao, Biao Liu, Cai-yun Heterogeneity of T3 stage esophageal squamous cell carcinoma in different parts based on enhanced CT radiomics |
title | Heterogeneity of T3 stage esophageal squamous cell carcinoma in different parts based on enhanced CT radiomics |
title_full | Heterogeneity of T3 stage esophageal squamous cell carcinoma in different parts based on enhanced CT radiomics |
title_fullStr | Heterogeneity of T3 stage esophageal squamous cell carcinoma in different parts based on enhanced CT radiomics |
title_full_unstemmed | Heterogeneity of T3 stage esophageal squamous cell carcinoma in different parts based on enhanced CT radiomics |
title_short | Heterogeneity of T3 stage esophageal squamous cell carcinoma in different parts based on enhanced CT radiomics |
title_sort | heterogeneity of t3 stage esophageal squamous cell carcinoma in different parts based on enhanced ct radiomics |
topic | 6800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593053/ https://www.ncbi.nlm.nih.gov/pubmed/32769880 http://dx.doi.org/10.1097/MD.0000000000021470 |
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