Cargando…

The HIV-1 latent reservoir is largely sensitive to circulating T cells

HIV-1-specific CD8+ T cells are an important component of HIV-1 curative strategies. Viral variants in the HIV-1 reservoir may limit the capacity of T cells to detect and clear virus-infected cells. We investigated the patterns of T cell escape variants in the replication-competent reservoir of 25 p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Warren, Joanna A, Zhou, Shuntai, Xu, Yinyan, Moeser, Matthew J, MacMillan, Daniel R, Council, Olivia, Kirchherr, Jennifer, Sung, Julia M, Roan, Nadia R, Adimora, Adaora A, Joseph, Sarah, Kuruc, JoAnn D, Gay, Cynthia L, Margolis, David M, Archin, Nancie, Brumme, Zabrina L, Swanstrom, Ronald, Goonetilleke, Nilu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593086/ https://www.ncbi.nlm.nih.gov/pubmed/33021198 http://dx.doi.org/10.7554/eLife.57246

Ejemplares similares

Vorinostat Renders the Replication-Competent Latent Reservoir of Human Immunodeficiency Virus (HIV) Vulnerable to Clearance by CD8 T Cells
por: Sung, Julia A., et al.
Publicado: (2017)

Reliable Estimation of CD8 T Cell Inhibition of In Vitro HIV-1 Replication
por: Xu, Yinyan, et al.
Publicado: (2021)

Corrigendum: Reliable estimation of CD8 T cell inhibition of in vitro HIV-1 replication
por: Xu, Yinyan, et al.
Publicado: (2023)

HIV-Specific T Cell Responses Are Highly Stable on Antiretroviral Therapy
por: Xu, Yinyan, et al.
Publicado: (2019)

Measuring the Inducible, Replication-Competent HIV Reservoir Using an Ultra-Sensitive p24 Readout, the Digital ELISA Viral Outgrowth Assay
por: Stuelke, Erin L., et al.
Publicado: (2020)

Dominant CD4(+) T cell receptors remain stable throughout antiretroviral therapy-mediated immune restoration in people with HIV
por: Sponaugle, Alexis, et al.
Publicado: (2023)

Peripheral Vγ9Vδ2 T Cells Are a Novel Reservoir of Latent HIV Infection
por: Soriano-Sarabia, Natalia, et al.
Publicado: (2015)

Blocking Formation of the Stable HIV Reservoir: A New Perspective for HIV-1 Cure
por: Goonetilleke, Nilu, et al.
Publicado: (2019)

New Frontiers in Measuring and Characterizing the HIV Reservoir
por: Falcinelli, Shane D., et al.
Publicado: (2019)

Assessing the impact of AGS-004, a dendritic cell-based immunotherapy, and vorinostat on persistent HIV-1 Infection
por: Gay, Cynthia L., et al.
Publicado: (2020)

Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1
por: Sanz, Marta, et al.
Publicado: (2023)

Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1
por: Sanz, Marta, et al.
Publicado: (2023)

The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function
por: Clutton, G., et al.
Publicado: (2016)

Corrigendum: The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function
por: Clutton, G., et al.
Publicado: (2016)

Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV Reservoirs
por: Brockman, Mark A., et al.
Publicado: (2015)

Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy
por: Tang, Yuyang, et al.
Publicado: (2023)

Sequence Evaluation and Comparative Analysis of Novel Assays for Intact Proviral HIV-1 DNA
por: Gaebler, Christian, et al.
Publicado: (2021)

HIV reservoirs are dominated by genetically younger and clonally enriched proviruses
por: Kinloch, Natalie N., et al.
Publicado: (2023)

The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time
por: Shahid, Aniqa, et al.
Publicado: (2023)

Depletion of HIV reservoir by activation of ISR signaling in resting CD4(+) T cells
por: Li, Dajiang, et al.
Publicado: (2022)

Sequential CCR5-Tropic HIV-1 Reactivation from Distinct Cellular Reservoirs following Perturbation of Elite Control
por: Watters, Sarah A., et al.
Publicado: (2016)

Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV
por: Ma, Tongcui, et al.
Publicado: (2022)

mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status
por: Neidleman, Jason, et al.
Publicado: (2021)

Fact and Fiction about 1%: Next Generation Sequencing and the Detection of Minor Drug Resistant Variants in HIV-1 Populations with and without Unique Molecular Identifiers
por: Zhou, Shuntai, et al.
Publicado: (2020)

Evaluation of EED Inhibitors as a Class of PRC2-Targeted Small Molecules for HIV Latency Reversal
por: Turner, Anne-Marie W., et al.
Publicado: (2020)

Selective HDAC Inhibition for the Disruption of Latent HIV-1 Infection
por: Barton, Kirston M., et al.
Publicado: (2014)

HIV-1 infection, response to treatment and establishment of viral latency in a novel humanized T cell-only mouse (TOM) model
por: Honeycutt, Jenna B, et al.
Publicado: (2013)

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1
por: Horvath, Riley M., et al.
Publicado: (2023)

A potent human neutralizing antibody Fc-dependently reduces established HBV infections
por: Li, Dan, et al.
Publicado: (2017)

Reactivation of latent HIV-1 in central memory CD4(+) T cells through TLR-1/2 stimulation
por: Novis, Camille L, et al.
Publicado: (2013)

Proviral Turnover During Untreated HIV Infection Is Dynamic and Variable Between Hosts, Impacting Reservoir Composition on ART
por: Brooks, Kelsie, et al.
Publicado: (2021)

Loss of GTPase activating protein neurofibromin stimulates paracrine cell communication via macropinocytosis
por: Ghoshal, Pushpankur, et al.
Publicado: (2019)

Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4(+) and CD8(+) T-lymphocytes
por: Moshfegh, C.M., et al.
Publicado: (2019)

Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction
por: Godo, Shigeo, et al.
Publicado: (2021)

Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials
por: Lorenzatti, Alberto J
Publicado: (2021)

Atherosclerotic Cardiovascular Disease in Rheumatoid Arthritis: Impact of Inflammation and Antirheumatic Treatment
por: Kerola, Anne Mirjam, et al.
Publicado: (2021)

The Role of C-reactive Protein in Patient Risk Stratification and Treatment
por: Arroyo-Espliguero, Ramón, et al.
Publicado: (2021)

Inflammation and Cardiovascular Disease: The Future
por: Arnold, Natalie, et al.
Publicado: (2021)

Small bowel stomas are associated with higher risk of circulating food-specific-IgG than patients with organic gastrointestinal conditions and colostomies
por: Carson, Walker K, et al.
Publicado: (2022)

Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells
por: Mouat, Isobel C, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4nrq7k4eu21lfsimh3qcb0at5q