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Perspective of a Pediatrician: Shared Pathogenesis of the Three Most Successful Pathogens of Children

Highly successful invasive pathogens exploit host vulnerabilities by adapting tools to co-opt highly conserved host features. This is especially true when pathogens develop ligands to hijack trafficking routes or signaling patterns of host receptors. In this context, highly successful pathogens can...

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Autor principal: Tuomanen, Elaine I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593378/
https://www.ncbi.nlm.nih.gov/pubmed/33178633
http://dx.doi.org/10.3389/fcimb.2020.585791
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author Tuomanen, Elaine I.
author_facet Tuomanen, Elaine I.
author_sort Tuomanen, Elaine I.
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description Highly successful invasive pathogens exploit host vulnerabilities by adapting tools to co-opt highly conserved host features. This is especially true when pathogens develop ligands to hijack trafficking routes or signaling patterns of host receptors. In this context, highly successful pathogens can be grouped together by the patterns of organs infected and diseases they cause. In the case of this perspective, the focus is on the historically most successful invasive bacterial pathogens of children that cause pneumonia, sepsis and meningitis: Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis. This triad shares a ligand to bind to PAF receptor to enter host cells despite early defenses by innate immunity. All three also target laminin receptor to cross endothelial barriers using a common set of molecular tools that may prove to be a design for a cross-protective vaccine.
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spelling pubmed-75933782020-11-10 Perspective of a Pediatrician: Shared Pathogenesis of the Three Most Successful Pathogens of Children Tuomanen, Elaine I. Front Cell Infect Microbiol Cellular and Infection Microbiology Highly successful invasive pathogens exploit host vulnerabilities by adapting tools to co-opt highly conserved host features. This is especially true when pathogens develop ligands to hijack trafficking routes or signaling patterns of host receptors. In this context, highly successful pathogens can be grouped together by the patterns of organs infected and diseases they cause. In the case of this perspective, the focus is on the historically most successful invasive bacterial pathogens of children that cause pneumonia, sepsis and meningitis: Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis. This triad shares a ligand to bind to PAF receptor to enter host cells despite early defenses by innate immunity. All three also target laminin receptor to cross endothelial barriers using a common set of molecular tools that may prove to be a design for a cross-protective vaccine. Frontiers Media S.A. 2020-10-15 /pmc/articles/PMC7593378/ /pubmed/33178633 http://dx.doi.org/10.3389/fcimb.2020.585791 Text en Copyright © 2020 Tuomanen http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Tuomanen, Elaine I.
Perspective of a Pediatrician: Shared Pathogenesis of the Three Most Successful Pathogens of Children
title Perspective of a Pediatrician: Shared Pathogenesis of the Three Most Successful Pathogens of Children
title_full Perspective of a Pediatrician: Shared Pathogenesis of the Three Most Successful Pathogens of Children
title_fullStr Perspective of a Pediatrician: Shared Pathogenesis of the Three Most Successful Pathogens of Children
title_full_unstemmed Perspective of a Pediatrician: Shared Pathogenesis of the Three Most Successful Pathogens of Children
title_short Perspective of a Pediatrician: Shared Pathogenesis of the Three Most Successful Pathogens of Children
title_sort perspective of a pediatrician: shared pathogenesis of the three most successful pathogens of children
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593378/
https://www.ncbi.nlm.nih.gov/pubmed/33178633
http://dx.doi.org/10.3389/fcimb.2020.585791
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