Comment on “Expression of CD44 and the survival in glioma: a meta-analysis”

CD44 has been considered as a cancer stem cell marker in various tumors. With great enthusiasm, we read an article written by Wu et al. entitled “Expression of CD44 and the survival in glioma: a meta-analysis” published in Bioscience Reports. The authors performed meta-analyses to study the prognost...

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Detalles Bibliográficos
Autores principales: Hou, Chongxian, Lin, Han, Wang, Peng, Yang, Yong, Cen, Siyi, Zhou, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593535/
https://www.ncbi.nlm.nih.gov/pubmed/33030522
http://dx.doi.org/10.1042/BSR20202812
Descripción
Sumario:CD44 has been considered as a cancer stem cell marker in various tumors. With great enthusiasm, we read an article written by Wu et al. entitled “Expression of CD44 and the survival in glioma: a meta-analysis” published in Bioscience Reports. The authors performed meta-analyses to study the prognostic significance of CD44 in gliomas, and drew the conclusion that high expression of CD44 may predict poor survival in glioma, particularly in WHO grade II–III gliomas. However, two major defects exist in the present study, which made the meta-analysis on the prognostic significance of CD44 in all gliomas unreliable. In this commentary, we discussed the limitations and significance of the present study.

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