Comment on “Expression of CD44 and the survival in glioma: a meta-analysis”

CD44 has been considered as a cancer stem cell marker in various tumors. With great enthusiasm, we read an article written by Wu et al. entitled “Expression of CD44 and the survival in glioma: a meta-analysis” published in Bioscience Reports. The authors performed meta-analyses to study the prognost...

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Autores principales: Hou, Chongxian, Lin, Han, Wang, Peng, Yang, Yong, Cen, Siyi, Zhou, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593535/
https://www.ncbi.nlm.nih.gov/pubmed/33030522
http://dx.doi.org/10.1042/BSR20202812
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author Hou, Chongxian
Lin, Han
Wang, Peng
Yang, Yong
Cen, Siyi
Zhou, Dong
author_facet Hou, Chongxian
Lin, Han
Wang, Peng
Yang, Yong
Cen, Siyi
Zhou, Dong
author_sort Hou, Chongxian
collection PubMed
description CD44 has been considered as a cancer stem cell marker in various tumors. With great enthusiasm, we read an article written by Wu et al. entitled “Expression of CD44 and the survival in glioma: a meta-analysis” published in Bioscience Reports. The authors performed meta-analyses to study the prognostic significance of CD44 in gliomas, and drew the conclusion that high expression of CD44 may predict poor survival in glioma, particularly in WHO grade II–III gliomas. However, two major defects exist in the present study, which made the meta-analysis on the prognostic significance of CD44 in all gliomas unreliable. In this commentary, we discussed the limitations and significance of the present study.
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spelling pubmed-75935352020-11-02 Comment on “Expression of CD44 and the survival in glioma: a meta-analysis” Hou, Chongxian Lin, Han Wang, Peng Yang, Yong Cen, Siyi Zhou, Dong Biosci Rep Cancer CD44 has been considered as a cancer stem cell marker in various tumors. With great enthusiasm, we read an article written by Wu et al. entitled “Expression of CD44 and the survival in glioma: a meta-analysis” published in Bioscience Reports. The authors performed meta-analyses to study the prognostic significance of CD44 in gliomas, and drew the conclusion that high expression of CD44 may predict poor survival in glioma, particularly in WHO grade II–III gliomas. However, two major defects exist in the present study, which made the meta-analysis on the prognostic significance of CD44 in all gliomas unreliable. In this commentary, we discussed the limitations and significance of the present study. Portland Press Ltd. 2020-10-28 /pmc/articles/PMC7593535/ /pubmed/33030522 http://dx.doi.org/10.1042/BSR20202812 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Cancer
Hou, Chongxian
Lin, Han
Wang, Peng
Yang, Yong
Cen, Siyi
Zhou, Dong
Comment on “Expression of CD44 and the survival in glioma: a meta-analysis”
title Comment on “Expression of CD44 and the survival in glioma: a meta-analysis”
title_full Comment on “Expression of CD44 and the survival in glioma: a meta-analysis”
title_fullStr Comment on “Expression of CD44 and the survival in glioma: a meta-analysis”
title_full_unstemmed Comment on “Expression of CD44 and the survival in glioma: a meta-analysis”
title_short Comment on “Expression of CD44 and the survival in glioma: a meta-analysis”
title_sort comment on “expression of cd44 and the survival in glioma: a meta-analysis”
topic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593535/
https://www.ncbi.nlm.nih.gov/pubmed/33030522
http://dx.doi.org/10.1042/BSR20202812
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