Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells

Human embryonic kidney cells HEK293 can be used for the production of therapeutic glycoproteins requiring human post-translational modifications. High cell density perfusion processes are advantageous for such production but are challenging due to the shear sensitivity of HEK293 cells. To understand...

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Detalles Bibliográficos
Autores principales: Zhan, Caijuan, Bidkhori, Gholamreza, Schwarz, Hubert, Malm, Magdalena, Mebrahtu, Aman, Field, Ray, Sellick, Christopher, Hatton, Diane, Varley, Paul, Mardinoglu, Adil, Rockberg, Johan, Chotteau, Veronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593556/
https://www.ncbi.nlm.nih.gov/pubmed/33145483
http://dx.doi.org/10.1016/j.isci.2020.101653

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