VISTA Re-programs Macrophage Biology Through the Combined Regulation of Tolerance and Anti-inflammatory Pathways

We present the novel finding that V-domain Ig suppressor of T cell activation (VISTA) negatively regulates innate inflammation through the transcriptional and epigenetic re-programming of macrophages. Representative of VISTA re-programming is the ability of VISTA agonistic antibodies to augment LPS...

Descripción completa

Detalles Bibliográficos
Autores principales: ElTanbouly, Mohamed A., Schaafsma, Evelien, Smits, Nicole C., Shah, Parth, Cheng, Chao, Burns, Christopher, Blazar, Bruce R., Noelle, Randolph J., Mabaera, Rodwell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593571/
https://www.ncbi.nlm.nih.gov/pubmed/33178206
http://dx.doi.org/10.3389/fimmu.2020.580187

Ejemplares similares

Ejemplares similares