Cargando…

Ustekinumab Inhibits T Follicular Helper Cell Differentiation in Patients With Crohn’s Disease

BACKGROUND & AIMS: The pathogenesis of chronic inflammatory bowel diseases (Crohn’s disease [CD] and ulcerative colitis) involves dysregulated TH1 and TH17 cell responses, which can be targeted therapeutically by the monoclonal antibody Ustekinumab directed against the joint p40 subunit of IL-12...

Descripción completa

Detalles Bibliográficos
Autores principales:	Globig, Anna-Maria, Sommer, Nikola Patricia, Wild, Katharina, Schardey, Josefine, Zoldan, Katharina, Thomann, Anne Kerstin, Schulte, Lucas-Alexander, Schreiner, Rupert, Reindl, Wolfgang, Klaus, Jochen, Schempp, Christoph Mathis, Hofmann, Maike, Thimme, Robert, Boettler, Tobias, Hasselblatt, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593584/ https://www.ncbi.nlm.nih.gov/pubmed/32679193 http://dx.doi.org/10.1016/j.jcmgh.2020.07.005

Ejemplares similares

Th1-Biased Hepatitis C Virus-Specific Follicular T Helper-Like Cells Effectively Support B Cells After Antiviral Therapy
por: Zoldan, Katharina, et al.
Publicado: (2021)

Follicular T Helper Cell Signatures in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis
por: Adam, Leonie, et al.
Publicado: (2018)

Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination
por: Wild, Katharina, et al.
Publicado: (2021)

Tofacitinib in Treatment-Refractory Moderate to Severe Ulcerative Colitis: Real-World Experience from a Retrospective Multicenter Observational Study
por: Hoffmann, Peter, et al.
Publicado: (2020)

Clinical utility of ustekinumab in Crohn’s disease
por: Kotze, Paulo Gustavo, et al.
Publicado: (2018)

Hypersensitivity to IV Ustekinumab but Tolerance to Subcutaneous Ustekinumab in a Patient With Crohn's Disease
por: Krugliak Cleveland, Noa, et al.
Publicado: (2020)

High Immunogenicity to Influenza Vaccination in Crohn’s Disease Patients Treated with Ustekinumab
por: Doornekamp, Laura, et al.
Publicado: (2020)

Rapid Resolution of Vulvar Crohn's Disease With Ustekinumab
por: Stoleru, Gianna, et al.
Publicado: (2020)

Successful Treatment of Oral Crohn’s Disease by Ustekinumab
por: Jukema, Jelmer B, et al.
Publicado: (2020)

Ustekinumab for Successful Treatment of Refractory Esophageal Crohn’s Disease
por: Barkin, Jodie A., et al.
Publicado: (2016)

Metastatic Vulval Crohn’s Disease With Good Outcome on Ustekinumab
por: Lim, Yizhe, et al.
Publicado: (2021)

A150 ASSOCIATION BETWEEN SERUM USTEKINUMAB CONCENTRATIONS AND ENDOSCOPIC DISEASE ACTIVITY IN CROHN’S DISEASE
por: Yanofsky, R, et al.
Publicado: (2022)

The frequency of follicular T helper cells differs in acute and chronic neuroinflammation
por: Baniahmad, Adalie, et al.
Publicado: (2020)

Ustekinumab and Vedolizumab Dual Biologic Therapy in the Treatment of Crohn's Disease
por: Liu, Eddie Y., et al.
Publicado: (2017)

Cost-effectiveness of ustekinumab in moderate to severe Crohn’s disease in Sweden
por: Hansson-Hedblom, Amanda, et al.
Publicado: (2018)

Cost of Refractory Crohn’s Disease Before and After Ustekinumab Utilization
por: Rahme, Elham, et al.
Publicado: (2019)

Successful Drug Desensitization to Ustekinumab in a Patient with Crohn's Disease
por: Cohen, Barrie, et al.
Publicado: (2021)

Ustekinumab in Crohn’s Disease: New Data for Positioning in Treatment Algorithm
por: D’Amico, Ferdinando, et al.
Publicado: (2022)

Exacerbation of Atopic Dermatitis Associated with Ustekinumab Treatment in Crohn's Disease
por: Andres, Brendan, et al.
Publicado: (2022)

Refractory metastatic Crohn’s disease responsive to ustekinumab dose intensification
por: Xiao, Teresa L., et al.
Publicado: (2022)

High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature
por: Globig, A.-M., et al.
Publicado: (2022)

Life of T Follicular Helper Cells
por: Suh, Woong-Kyung
Publicado: (2015)

Intrinsic neural network dysfunction in quiescent Crohn’s Disease
por: Thomann, Anne K., et al.
Publicado: (2017)

Profile of ustekinumab and its potential in patients with moderate-to-severe Crohn’s disease
por: Tuskey, Anne, et al.
Publicado: (2014)

Ustekinumab in treatment of Crohn’s disease: design, development, and potential place in therapy
por: Deepak, Parakkal, et al.
Publicado: (2016)

Posterior Reversible Encephalopathy Syndrome following Ustekinumab Induction for Crohn's Disease
por: Mishra, Avantika, et al.
Publicado: (2018)

Ustekinumab dose escalation improves clinical responses in refractory Crohn’s disease
por: Haider, Syedreza A., et al.
Publicado: (2020)

An Australian Real-World Study of Treatment Persistence of Ustekinumab in Crohn’s Disease
por: Chien, Tzu Hsiang, et al.
Publicado: (2021)

Ustekinumab and Vedolizumab Are Equally Safe and Effective in Elderly Crohn’s Disease Patients
por: Gebeyehu, Gerum Gashaw, et al.
Publicado: (2022)

Ustekinumab Trough Concentrations Are Associated with Biochemical Outcomes in Patients with Crohn’s Disease
por: Straatmijer, Tessa, et al.
Publicado: (2023)

SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis
por: Boettler, Tobias, et al.
Publicado: (2022)

Plasma Cyclic Guanosine Monophosphate Is a Promising Biomarker of Clinically Significant Portal Hypertension in Patients With Liver Cirrhosis
por: Sturm, Lukas, et al.
Publicado: (2022)

Interstitial Granulomatous Drug Reaction to Ustekinumab
por: Walker, A., et al.
Publicado: (2022)

Interleukin-1 in the Response of Follicular Helper and Follicular Regulatory T Cells
por: Ritvo, Paul-Gydéon, et al.
Publicado: (2019)

T follicular helper cells and T follicular regulatory cells in autoimmune diseases
por: Qi, Jingjing, et al.
Publicado: (2023)

Regulation of T follicular helper cells by ICOS
por: Hutloff, Andreas
Publicado: (2015)

Follicular helper T cell in immunity and autoimmunity
por: Mesquita, D., et al.
Publicado: (2016)

T Follicular Helper Cells in Autoimmune Disorders
por: Gensous, Noémie, et al.
Publicado: (2018)

Primary cutaneous T‐follicular helper lymphoma
por: Fenu, Elena M., et al.
Publicado: (2023)

Efficacy of ustekinumab against infliximab-induced psoriasis and arthritis associated with Crohn’s disease
por: Matsumoto, Satohiro, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0t9jav95s0v50776482b94dtu4