H4K20 monomethylation inhibition causes loss of genomic integrity in mouse preimplantation embryos

Maintaining genomic integrity in mammalian early embryos, which are deficient in DNA damage repair, is critical for normal preimplantation and subsequent development. Abnormalities in DNA damage repair in preimplantation embryos can cause not only developmental arrest, but also diseases such as cong...

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Detalles Bibliográficos
Autores principales: SHIKATA, Daiki, YAMAMOTO, Takuto, HONDA, Shinnosuke, IKEDA, Shuntaro, MINAMI, Naojiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Society for Reproduction and Development 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593633/
https://www.ncbi.nlm.nih.gov/pubmed/32378528
http://dx.doi.org/10.1262/jrd.2020-036

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