Cargando…

Discovery of a novel kinase hinge binder fragment by dynamic undocking

One of the key motifs of type I kinase inhibitors is their interactions with the hinge region of ATP binding sites. These interactions contribute significantly to the potency of the inhibitors; however, only a tiny fraction of the available chemical space has been explored with kinase inhibitors rep...

Descripción completa

Detalles Bibliográficos
Autores principales: Rachman, Moira, Bajusz, Dávid, Hetényi, Anasztázia, Scarpino, Andrea, Merő, Balázs, Egyed, Attila, Buday, László, Barril, Xavier, Keserű, György M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593776/
https://www.ncbi.nlm.nih.gov/pubmed/33479656
http://dx.doi.org/10.1039/c9md00519f

Ejemplares similares