Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated With MAPT, GRN, and C9orf72 Pathogenic Variants

IMPORTANCE: Several clinical trials are planned for familial forms of frontotemporal lobar degeneration (f-FTLD). Precise modeling of brain atrophy in f-FTLD could improve the power to detect a treatment effect. OBJECTIVE: To characterize regions and rates of atrophy in the 3 primary f-FTLD genetic...

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Detalles Bibliográficos
Autores principales: Staffaroni, Adam M., Goh, Sheng-Yang M., Cobigo, Yann, Ong, Elise, Lee, Suzee E., Casaletto, Kaitlin B., Wolf, Amy, Forsberg, Leah K., Ghoshal, Nupur, Graff-Radford, Neill R., Grossman, Murray, Heuer, Hilary W., Hsiung, Ging-Yuek R., Kantarci, Kejal, Knopman, David S., Kremers, Walter K., Mackenzie, Ian R., Miller, Bruce L., Pedraza, Otto, Rascovsky, Katya, Tartaglia, M. Carmela, Wszolek, Zbigniew K., Kramer, Joel H., Kornak, John, Boeve, Bradley F., Boxer, Adam L., Rosen, Howard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2020
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593814/
https://www.ncbi.nlm.nih.gov/pubmed/33112398
http://dx.doi.org/10.1001/jamanetworkopen.2020.22847

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