Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential

Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the last decade and the first CLK inhibitor, compound SM...

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Detalles Bibliográficos
Autores principales: Martín Moyano, Paula, Němec, Václav, Paruch, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593917/
https://www.ncbi.nlm.nih.gov/pubmed/33066143
http://dx.doi.org/10.3390/ijms21207549
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author Martín Moyano, Paula
Němec, Václav
Paruch, Kamil
author_facet Martín Moyano, Paula
Němec, Václav
Paruch, Kamil
author_sort Martín Moyano, Paula
collection PubMed
description Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the last decade and the first CLK inhibitor, compound SM08502, entered clinical trials only recently. This review summarizes the biological roles and therapeutic potential of CLKs and their heretofore published small-molecule inhibitors, with a focus on the compounds’ potential to be utilized as quality chemical biology probes.
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spelling pubmed-75939172020-10-30 Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential Martín Moyano, Paula Němec, Václav Paruch, Kamil Int J Mol Sci Review Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the last decade and the first CLK inhibitor, compound SM08502, entered clinical trials only recently. This review summarizes the biological roles and therapeutic potential of CLKs and their heretofore published small-molecule inhibitors, with a focus on the compounds’ potential to be utilized as quality chemical biology probes. MDPI 2020-10-13 /pmc/articles/PMC7593917/ /pubmed/33066143 http://dx.doi.org/10.3390/ijms21207549 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martín Moyano, Paula
Němec, Václav
Paruch, Kamil
Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential
title Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential
title_full Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential
title_fullStr Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential
title_full_unstemmed Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential
title_short Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential
title_sort cdc-like kinases (clks): biology, chemical probes, and therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593917/
https://www.ncbi.nlm.nih.gov/pubmed/33066143
http://dx.doi.org/10.3390/ijms21207549
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