Ovarian Transcriptomic Analysis Reveals Differential Expression Genes Associated with Cell Death Process after Selection for Ovulation Rate in Rabbits

SIMPLE SUMMARY: Transcriptomic analysis showed nineteen potential biomarkers in ovarian tissue from females belonged to a rabbit line selected for ovulation rate for 10 generations and the control line. These females differed not only in ovulation rate but also in prenatal survival since similar lit...

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Autores principales: Serna-García, Marta, Peiró, Rosa, Serna, Eva, Santacreu, María Antonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593938/
https://www.ncbi.nlm.nih.gov/pubmed/33092110
http://dx.doi.org/10.3390/ani10101924
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author Serna-García, Marta
Peiró, Rosa
Serna, Eva
Santacreu, María Antonia
author_facet Serna-García, Marta
Peiró, Rosa
Serna, Eva
Santacreu, María Antonia
author_sort Serna-García, Marta
collection PubMed
description SIMPLE SUMMARY: Transcriptomic analysis showed nineteen potential biomarkers in ovarian tissue from females belonged to a rabbit line selected for ovulation rate for 10 generations and the control line. These females differed not only in ovulation rate but also in prenatal survival since similar litter size were observed. ABSTRACT: Litter size is an essential trait in rabbit meat production but with low heritability. A selection experiment for ovulation rate has been performed for 10 generations to improve litter size in rabbits. The selected line increased two ova more than the control line but nevertheless a negative correlation was observed with prenatal survival. A transcriptomic study was performed, using microarrays, in ovarian tissue from females belonging to the selected line and the control line. Our results showed 1357 differential expressed genes and nineteen potential biomarkers associated with prenatal mortality, which could explain differences between litter size in rabbits. Cell death was the most relevant process.
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spelling pubmed-75939382020-10-30 Ovarian Transcriptomic Analysis Reveals Differential Expression Genes Associated with Cell Death Process after Selection for Ovulation Rate in Rabbits Serna-García, Marta Peiró, Rosa Serna, Eva Santacreu, María Antonia Animals (Basel) Article SIMPLE SUMMARY: Transcriptomic analysis showed nineteen potential biomarkers in ovarian tissue from females belonged to a rabbit line selected for ovulation rate for 10 generations and the control line. These females differed not only in ovulation rate but also in prenatal survival since similar litter size were observed. ABSTRACT: Litter size is an essential trait in rabbit meat production but with low heritability. A selection experiment for ovulation rate has been performed for 10 generations to improve litter size in rabbits. The selected line increased two ova more than the control line but nevertheless a negative correlation was observed with prenatal survival. A transcriptomic study was performed, using microarrays, in ovarian tissue from females belonging to the selected line and the control line. Our results showed 1357 differential expressed genes and nineteen potential biomarkers associated with prenatal mortality, which could explain differences between litter size in rabbits. Cell death was the most relevant process. MDPI 2020-10-20 /pmc/articles/PMC7593938/ /pubmed/33092110 http://dx.doi.org/10.3390/ani10101924 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Serna-García, Marta
Peiró, Rosa
Serna, Eva
Santacreu, María Antonia
Ovarian Transcriptomic Analysis Reveals Differential Expression Genes Associated with Cell Death Process after Selection for Ovulation Rate in Rabbits
title Ovarian Transcriptomic Analysis Reveals Differential Expression Genes Associated with Cell Death Process after Selection for Ovulation Rate in Rabbits
title_full Ovarian Transcriptomic Analysis Reveals Differential Expression Genes Associated with Cell Death Process after Selection for Ovulation Rate in Rabbits
title_fullStr Ovarian Transcriptomic Analysis Reveals Differential Expression Genes Associated with Cell Death Process after Selection for Ovulation Rate in Rabbits
title_full_unstemmed Ovarian Transcriptomic Analysis Reveals Differential Expression Genes Associated with Cell Death Process after Selection for Ovulation Rate in Rabbits
title_short Ovarian Transcriptomic Analysis Reveals Differential Expression Genes Associated with Cell Death Process after Selection for Ovulation Rate in Rabbits
title_sort ovarian transcriptomic analysis reveals differential expression genes associated with cell death process after selection for ovulation rate in rabbits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593938/
https://www.ncbi.nlm.nih.gov/pubmed/33092110
http://dx.doi.org/10.3390/ani10101924
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