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Aberrant Intracellular pH Regulation Limiting Glyceraldehyde-3-Phosphate Dehydrogenase Activity in the Glucose-Sensitive Yeast tps1Δ Mutant

Whereas the yeast Saccharomyces cerevisiae shows great preference for glucose as a carbon source, a deletion mutant in trehalose-6-phosphate synthase, tps1Δ, is highly sensitive to even a few millimolar glucose, which triggers apoptosis and cell death. Glucose addition to tps1Δ cells causes deregula...

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Detalles Bibliográficos
Autores principales:	Van Leemputte, Frederik, Vanthienen, Ward, Wijnants, Stefanie, Van Zeebroeck, Griet, Thevelein, Johan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593968/ https://www.ncbi.nlm.nih.gov/pubmed/33109759 http://dx.doi.org/10.1128/mBio.02199-20

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