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Can Measurements of Inflammatory Biomarkers Be Used to Spot Respiratory Viral Infections?

Accurate detection of human respiratory viral infections is highly topical. We investigated how strongly inflammatory biomarkers (FeNO, eosinophils, neutrophils, and cytokines in nasal lavage fluid) and lung function parameters change upon rhinovirus 16 infection, in order to explore their potential...

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Autores principales: Sinha, Anirban, Lutter, René, Dekker, Tamara, Dierdorp, Barbara, J. Sterk, Peter, Frey, Urs, Delgado-Eckert, Edgar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594027/
https://www.ncbi.nlm.nih.gov/pubmed/33080844
http://dx.doi.org/10.3390/v12101175
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author Sinha, Anirban
Lutter, René
Dekker, Tamara
Dierdorp, Barbara
J. Sterk, Peter
Frey, Urs
Delgado-Eckert, Edgar
author_facet Sinha, Anirban
Lutter, René
Dekker, Tamara
Dierdorp, Barbara
J. Sterk, Peter
Frey, Urs
Delgado-Eckert, Edgar
author_sort Sinha, Anirban
collection PubMed
description Accurate detection of human respiratory viral infections is highly topical. We investigated how strongly inflammatory biomarkers (FeNO, eosinophils, neutrophils, and cytokines in nasal lavage fluid) and lung function parameters change upon rhinovirus 16 infection, in order to explore their potential use for infection detection. To this end, within a longitudinal cohort study, healthy and mildly asthmatic volunteers were experimentally inoculated with rhinovirus 16, and time series of these parameters/biomarkers were systematically recorded and compared between the pre- and post-infection phases of the study, which lasted two months and one month, respectively. We found that the parameters’/biomarkers’ ability to discriminate between the infected and the uninfected state varied over the observation time period. Consistently over time, the concentration of cytokines, in nasal lavage fluid, showed moderate to very good discrimination performance, thereby qualifying for disease progression monitoring, whereas lung function and FeNO, while quickly and non-invasively measurable using cheap portable devices (e.g., at airports), performed poorly.
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spelling pubmed-75940272020-10-30 Can Measurements of Inflammatory Biomarkers Be Used to Spot Respiratory Viral Infections? Sinha, Anirban Lutter, René Dekker, Tamara Dierdorp, Barbara J. Sterk, Peter Frey, Urs Delgado-Eckert, Edgar Viruses Article Accurate detection of human respiratory viral infections is highly topical. We investigated how strongly inflammatory biomarkers (FeNO, eosinophils, neutrophils, and cytokines in nasal lavage fluid) and lung function parameters change upon rhinovirus 16 infection, in order to explore their potential use for infection detection. To this end, within a longitudinal cohort study, healthy and mildly asthmatic volunteers were experimentally inoculated with rhinovirus 16, and time series of these parameters/biomarkers were systematically recorded and compared between the pre- and post-infection phases of the study, which lasted two months and one month, respectively. We found that the parameters’/biomarkers’ ability to discriminate between the infected and the uninfected state varied over the observation time period. Consistently over time, the concentration of cytokines, in nasal lavage fluid, showed moderate to very good discrimination performance, thereby qualifying for disease progression monitoring, whereas lung function and FeNO, while quickly and non-invasively measurable using cheap portable devices (e.g., at airports), performed poorly. MDPI 2020-10-17 /pmc/articles/PMC7594027/ /pubmed/33080844 http://dx.doi.org/10.3390/v12101175 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sinha, Anirban
Lutter, René
Dekker, Tamara
Dierdorp, Barbara
J. Sterk, Peter
Frey, Urs
Delgado-Eckert, Edgar
Can Measurements of Inflammatory Biomarkers Be Used to Spot Respiratory Viral Infections?
title Can Measurements of Inflammatory Biomarkers Be Used to Spot Respiratory Viral Infections?
title_full Can Measurements of Inflammatory Biomarkers Be Used to Spot Respiratory Viral Infections?
title_fullStr Can Measurements of Inflammatory Biomarkers Be Used to Spot Respiratory Viral Infections?
title_full_unstemmed Can Measurements of Inflammatory Biomarkers Be Used to Spot Respiratory Viral Infections?
title_short Can Measurements of Inflammatory Biomarkers Be Used to Spot Respiratory Viral Infections?
title_sort can measurements of inflammatory biomarkers be used to spot respiratory viral infections?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594027/
https://www.ncbi.nlm.nih.gov/pubmed/33080844
http://dx.doi.org/10.3390/v12101175
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