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Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications
Perinatal stem cells have been regarded as an attractive and available cell source for medical research and clinical trials in recent years. Multiple stem cell types have been identified in the human placenta. Recent advances in knowledge on placental stem cells have revealed that human amniotic epi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594030/ https://www.ncbi.nlm.nih.gov/pubmed/33086620 http://dx.doi.org/10.3390/ijms21207730 |
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author | Qiu, Chen Ge, Zhen Cui, Wenyu Yu, Luyang Li, Jinying |
author_facet | Qiu, Chen Ge, Zhen Cui, Wenyu Yu, Luyang Li, Jinying |
author_sort | Qiu, Chen |
collection | PubMed |
description | Perinatal stem cells have been regarded as an attractive and available cell source for medical research and clinical trials in recent years. Multiple stem cell types have been identified in the human placenta. Recent advances in knowledge on placental stem cells have revealed that human amniotic epithelial stem cells (hAESCs) have obvious advantages and can be used as a novel potential cell source for cellular therapy and clinical application. hAESCs are known to possess stem-cell-like plasticity, immune-privilege, and paracrine properties. In addition, non-tumorigenicity and a lack of ethical concerns are two major advantages compared with embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). All of the characteristics mentioned above and other additional advantages, including easy accessibility and a non-invasive application procedure, make hAESCs a potential ideal cell type for use in both research and regenerative medicine in the near future. This review article summarizes current knowledge on the characteristics, therapeutic potential, clinical advances and future challenges of hAESCs in detail. |
format | Online Article Text |
id | pubmed-7594030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75940302020-10-30 Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications Qiu, Chen Ge, Zhen Cui, Wenyu Yu, Luyang Li, Jinying Int J Mol Sci Review Perinatal stem cells have been regarded as an attractive and available cell source for medical research and clinical trials in recent years. Multiple stem cell types have been identified in the human placenta. Recent advances in knowledge on placental stem cells have revealed that human amniotic epithelial stem cells (hAESCs) have obvious advantages and can be used as a novel potential cell source for cellular therapy and clinical application. hAESCs are known to possess stem-cell-like plasticity, immune-privilege, and paracrine properties. In addition, non-tumorigenicity and a lack of ethical concerns are two major advantages compared with embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). All of the characteristics mentioned above and other additional advantages, including easy accessibility and a non-invasive application procedure, make hAESCs a potential ideal cell type for use in both research and regenerative medicine in the near future. This review article summarizes current knowledge on the characteristics, therapeutic potential, clinical advances and future challenges of hAESCs in detail. MDPI 2020-10-19 /pmc/articles/PMC7594030/ /pubmed/33086620 http://dx.doi.org/10.3390/ijms21207730 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Qiu, Chen Ge, Zhen Cui, Wenyu Yu, Luyang Li, Jinying Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications |
title | Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications |
title_full | Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications |
title_fullStr | Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications |
title_full_unstemmed | Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications |
title_short | Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications |
title_sort | human amniotic epithelial stem cells: a promising seed cell for clinical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594030/ https://www.ncbi.nlm.nih.gov/pubmed/33086620 http://dx.doi.org/10.3390/ijms21207730 |
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