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NMR as a “Gold Standard” Method in Drug Design and Discovery

Studying disease models at the molecular level is vital for drug development in order to improve treatment and prevent a wide range of human pathologies. Microbial infections are still a major challenge because pathogens rapidly and continually evolve developing drug resistance. Cancer cells also ch...

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Autores principales: Emwas, Abdul-Hamid, Szczepski, Kacper, Poulson, Benjamin Gabriel, Chandra, Kousik, McKay, Ryan T., Dhahri, Manel, Alahmari, Fatimah, Jaremko, Lukasz, Lachowicz, Joanna Izabela, Jaremko, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594251/
https://www.ncbi.nlm.nih.gov/pubmed/33050240
http://dx.doi.org/10.3390/molecules25204597
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author Emwas, Abdul-Hamid
Szczepski, Kacper
Poulson, Benjamin Gabriel
Chandra, Kousik
McKay, Ryan T.
Dhahri, Manel
Alahmari, Fatimah
Jaremko, Lukasz
Lachowicz, Joanna Izabela
Jaremko, Mariusz
author_facet Emwas, Abdul-Hamid
Szczepski, Kacper
Poulson, Benjamin Gabriel
Chandra, Kousik
McKay, Ryan T.
Dhahri, Manel
Alahmari, Fatimah
Jaremko, Lukasz
Lachowicz, Joanna Izabela
Jaremko, Mariusz
author_sort Emwas, Abdul-Hamid
collection PubMed
description Studying disease models at the molecular level is vital for drug development in order to improve treatment and prevent a wide range of human pathologies. Microbial infections are still a major challenge because pathogens rapidly and continually evolve developing drug resistance. Cancer cells also change genetically, and current therapeutic techniques may be (or may become) ineffective in many cases. The pathology of many neurological diseases remains an enigma, and the exact etiology and underlying mechanisms are still largely unknown. Viral infections spread and develop much more quickly than does the corresponding research needed to prevent and combat these infections; the present and most relevant outbreak of SARS-CoV-2, which originated in Wuhan, China, illustrates the critical and immediate need to improve drug design and development techniques. Modern day drug discovery is a time-consuming, expensive process. Each new drug takes in excess of 10 years to develop and costs on average more than a billion US dollars. This demonstrates the need of a complete redesign or novel strategies. Nuclear Magnetic Resonance (NMR) has played a critical role in drug discovery ever since its introduction several decades ago. In just three decades, NMR has become a “gold standard” platform technology in medical and pharmacology studies. In this review, we present the major applications of NMR spectroscopy in medical drug discovery and development. The basic concepts, theories, and applications of the most commonly used NMR techniques are presented. We also summarize the advantages and limitations of the primary NMR methods in drug development.
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spelling pubmed-75942512020-10-30 NMR as a “Gold Standard” Method in Drug Design and Discovery Emwas, Abdul-Hamid Szczepski, Kacper Poulson, Benjamin Gabriel Chandra, Kousik McKay, Ryan T. Dhahri, Manel Alahmari, Fatimah Jaremko, Lukasz Lachowicz, Joanna Izabela Jaremko, Mariusz Molecules Review Studying disease models at the molecular level is vital for drug development in order to improve treatment and prevent a wide range of human pathologies. Microbial infections are still a major challenge because pathogens rapidly and continually evolve developing drug resistance. Cancer cells also change genetically, and current therapeutic techniques may be (or may become) ineffective in many cases. The pathology of many neurological diseases remains an enigma, and the exact etiology and underlying mechanisms are still largely unknown. Viral infections spread and develop much more quickly than does the corresponding research needed to prevent and combat these infections; the present and most relevant outbreak of SARS-CoV-2, which originated in Wuhan, China, illustrates the critical and immediate need to improve drug design and development techniques. Modern day drug discovery is a time-consuming, expensive process. Each new drug takes in excess of 10 years to develop and costs on average more than a billion US dollars. This demonstrates the need of a complete redesign or novel strategies. Nuclear Magnetic Resonance (NMR) has played a critical role in drug discovery ever since its introduction several decades ago. In just three decades, NMR has become a “gold standard” platform technology in medical and pharmacology studies. In this review, we present the major applications of NMR spectroscopy in medical drug discovery and development. The basic concepts, theories, and applications of the most commonly used NMR techniques are presented. We also summarize the advantages and limitations of the primary NMR methods in drug development. MDPI 2020-10-09 /pmc/articles/PMC7594251/ /pubmed/33050240 http://dx.doi.org/10.3390/molecules25204597 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Emwas, Abdul-Hamid
Szczepski, Kacper
Poulson, Benjamin Gabriel
Chandra, Kousik
McKay, Ryan T.
Dhahri, Manel
Alahmari, Fatimah
Jaremko, Lukasz
Lachowicz, Joanna Izabela
Jaremko, Mariusz
NMR as a “Gold Standard” Method in Drug Design and Discovery
title NMR as a “Gold Standard” Method in Drug Design and Discovery
title_full NMR as a “Gold Standard” Method in Drug Design and Discovery
title_fullStr NMR as a “Gold Standard” Method in Drug Design and Discovery
title_full_unstemmed NMR as a “Gold Standard” Method in Drug Design and Discovery
title_short NMR as a “Gold Standard” Method in Drug Design and Discovery
title_sort nmr as a “gold standard” method in drug design and discovery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594251/
https://www.ncbi.nlm.nih.gov/pubmed/33050240
http://dx.doi.org/10.3390/molecules25204597
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