Cyclometalated Iridium Complex-Catalyzed N-Alkylation of Amines with Alcohols via Borrowing Hydrogen in Aqueous Media

[Image: see text] This paper develops a methodology for cyclometalated iridium complex-catalyzed N-alkylation of amines with alcohols via borrowing hydrogen in the aqueous phase. The cyclometalated iridium catalyst-mediated N-alkylation of amines with alcohols displays high activity (S/C up to 10,00...

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Autores principales: Luo, NianHua, Zhong, YuHong, Wen, HuiLing, Luo, Renshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594325/
https://www.ncbi.nlm.nih.gov/pubmed/33134736
http://dx.doi.org/10.1021/acsomega.0c04192
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author Luo, NianHua
Zhong, YuHong
Wen, HuiLing
Luo, Renshi
author_facet Luo, NianHua
Zhong, YuHong
Wen, HuiLing
Luo, Renshi
author_sort Luo, NianHua
collection PubMed
description [Image: see text] This paper develops a methodology for cyclometalated iridium complex-catalyzed N-alkylation of amines with alcohols via borrowing hydrogen in the aqueous phase. The cyclometalated iridium catalyst-mediated N-alkylation of amines with alcohols displays high activity (S/C up to 10,000 and yield up to 96%) and ratio of amine/imine (up to >99:1) in a broad range of substrates (up to 46 examples) using water as the green and eco-friendly solvent. Most importantly, this transformation is simple, efficient, and can be performed at a gram scale, showcasing its potential for industrially synthesizing N-alkylamine compounds.
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spelling pubmed-75943252020-10-30 Cyclometalated Iridium Complex-Catalyzed N-Alkylation of Amines with Alcohols via Borrowing Hydrogen in Aqueous Media Luo, NianHua Zhong, YuHong Wen, HuiLing Luo, Renshi ACS Omega [Image: see text] This paper develops a methodology for cyclometalated iridium complex-catalyzed N-alkylation of amines with alcohols via borrowing hydrogen in the aqueous phase. The cyclometalated iridium catalyst-mediated N-alkylation of amines with alcohols displays high activity (S/C up to 10,000 and yield up to 96%) and ratio of amine/imine (up to >99:1) in a broad range of substrates (up to 46 examples) using water as the green and eco-friendly solvent. Most importantly, this transformation is simple, efficient, and can be performed at a gram scale, showcasing its potential for industrially synthesizing N-alkylamine compounds. American Chemical Society 2020-10-19 /pmc/articles/PMC7594325/ /pubmed/33134736 http://dx.doi.org/10.1021/acsomega.0c04192 Text en © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Luo, NianHua
Zhong, YuHong
Wen, HuiLing
Luo, Renshi
Cyclometalated Iridium Complex-Catalyzed N-Alkylation of Amines with Alcohols via Borrowing Hydrogen in Aqueous Media
title Cyclometalated Iridium Complex-Catalyzed N-Alkylation of Amines with Alcohols via Borrowing Hydrogen in Aqueous Media
title_full Cyclometalated Iridium Complex-Catalyzed N-Alkylation of Amines with Alcohols via Borrowing Hydrogen in Aqueous Media
title_fullStr Cyclometalated Iridium Complex-Catalyzed N-Alkylation of Amines with Alcohols via Borrowing Hydrogen in Aqueous Media
title_full_unstemmed Cyclometalated Iridium Complex-Catalyzed N-Alkylation of Amines with Alcohols via Borrowing Hydrogen in Aqueous Media
title_short Cyclometalated Iridium Complex-Catalyzed N-Alkylation of Amines with Alcohols via Borrowing Hydrogen in Aqueous Media
title_sort cyclometalated iridium complex-catalyzed n-alkylation of amines with alcohols via borrowing hydrogen in aqueous media
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594325/
https://www.ncbi.nlm.nih.gov/pubmed/33134736
http://dx.doi.org/10.1021/acsomega.0c04192
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AT wenhuiling cyclometalatediridiumcomplexcatalyzednalkylationofamineswithalcoholsviaborrowinghydrogeninaqueousmedia
AT luorenshi cyclometalatediridiumcomplexcatalyzednalkylationofamineswithalcoholsviaborrowinghydrogeninaqueousmedia

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