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The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19

Studies on severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) suggest a protective effect of anti-A antibodies against viral cell entry that may hold relevance for SARS-CoV-2 infection. Therefore, we aimed to determine whether ABO blood groups are associated with different severities of CO...

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Autores principales: Hoiland, Ryan L., Fergusson, Nicholas A., Mitra, Anish R., Griesdale, Donald E. G., Devine, Dana V., Stukas, Sophie, Cooper, Jennifer, Thiara, Sonny, Foster, Denise, Chen, Luke Y. C., Lee, Agnes Y. Y., Conway, Edward M., Wellington, Cheryl L., Sekhon, Mypinder S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594392/
https://www.ncbi.nlm.nih.gov/pubmed/33057633
http://dx.doi.org/10.1182/bloodadvances.2020002623
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author Hoiland, Ryan L.
Fergusson, Nicholas A.
Mitra, Anish R.
Griesdale, Donald E. G.
Devine, Dana V.
Stukas, Sophie
Cooper, Jennifer
Thiara, Sonny
Foster, Denise
Chen, Luke Y. C.
Lee, Agnes Y. Y.
Conway, Edward M.
Wellington, Cheryl L.
Sekhon, Mypinder S.
author_facet Hoiland, Ryan L.
Fergusson, Nicholas A.
Mitra, Anish R.
Griesdale, Donald E. G.
Devine, Dana V.
Stukas, Sophie
Cooper, Jennifer
Thiara, Sonny
Foster, Denise
Chen, Luke Y. C.
Lee, Agnes Y. Y.
Conway, Edward M.
Wellington, Cheryl L.
Sekhon, Mypinder S.
author_sort Hoiland, Ryan L.
collection PubMed
description Studies on severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) suggest a protective effect of anti-A antibodies against viral cell entry that may hold relevance for SARS-CoV-2 infection. Therefore, we aimed to determine whether ABO blood groups are associated with different severities of COVID-19. We conducted a multicenter retrospective analysis and nested prospective observational substudy of critically ill patients with COVID-19. We collected data pertaining to age, sex, comorbidities, dates of symptom onset, hospital admission, intensive care unit (ICU) admission, mechanical ventilation, continuous renal replacement therapy (CRRT), standard laboratory parameters, and serum inflammatory cytokines. National (N = 398 671; P = .38) and provincial (n = 62 246; P = .60) ABO blood group distributions did not differ from our cohort (n = 95). A higher proportion of COVID-19 patients with blood group A or AB required mechanical ventilation (P = .02) and CRRT (P = .004) and had a longer ICU stay (P = .03) compared with patients with blood group O or B. Blood group A or AB also had an increased probability of requiring mechanical ventilation and CRRT after adjusting for age, sex, and presence of ≥1 comorbidity. Inflammatory cytokines did not differ between patients with blood group A or AB (n = 11) vs O or B (n = 14; P > .10 for all cytokines). Collectively, our data indicate that critically ill COVID-19 patients with blood group A or AB are at increased risk for requiring mechanical ventilation, CRRT, and prolonged ICU admission compared with patients with blood group O or B. Further work is needed to understand the underlying mechanisms.
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spelling pubmed-75943922020-10-29 The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19 Hoiland, Ryan L. Fergusson, Nicholas A. Mitra, Anish R. Griesdale, Donald E. G. Devine, Dana V. Stukas, Sophie Cooper, Jennifer Thiara, Sonny Foster, Denise Chen, Luke Y. C. Lee, Agnes Y. Y. Conway, Edward M. Wellington, Cheryl L. Sekhon, Mypinder S. Blood Adv Clinical Trials and Observations Studies on severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) suggest a protective effect of anti-A antibodies against viral cell entry that may hold relevance for SARS-CoV-2 infection. Therefore, we aimed to determine whether ABO blood groups are associated with different severities of COVID-19. We conducted a multicenter retrospective analysis and nested prospective observational substudy of critically ill patients with COVID-19. We collected data pertaining to age, sex, comorbidities, dates of symptom onset, hospital admission, intensive care unit (ICU) admission, mechanical ventilation, continuous renal replacement therapy (CRRT), standard laboratory parameters, and serum inflammatory cytokines. National (N = 398 671; P = .38) and provincial (n = 62 246; P = .60) ABO blood group distributions did not differ from our cohort (n = 95). A higher proportion of COVID-19 patients with blood group A or AB required mechanical ventilation (P = .02) and CRRT (P = .004) and had a longer ICU stay (P = .03) compared with patients with blood group O or B. Blood group A or AB also had an increased probability of requiring mechanical ventilation and CRRT after adjusting for age, sex, and presence of ≥1 comorbidity. Inflammatory cytokines did not differ between patients with blood group A or AB (n = 11) vs O or B (n = 14; P > .10 for all cytokines). Collectively, our data indicate that critically ill COVID-19 patients with blood group A or AB are at increased risk for requiring mechanical ventilation, CRRT, and prolonged ICU admission compared with patients with blood group O or B. Further work is needed to understand the underlying mechanisms. American Society of Hematology 2020-10-14 /pmc/articles/PMC7594392/ /pubmed/33057633 http://dx.doi.org/10.1182/bloodadvances.2020002623 Text en © 2020 by The American Society of Hematology This article is made available via the PMC Open Access Subset for unrestricted reuse and analyses in any form or by any means with acknowledgment of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Clinical Trials and Observations
Hoiland, Ryan L.
Fergusson, Nicholas A.
Mitra, Anish R.
Griesdale, Donald E. G.
Devine, Dana V.
Stukas, Sophie
Cooper, Jennifer
Thiara, Sonny
Foster, Denise
Chen, Luke Y. C.
Lee, Agnes Y. Y.
Conway, Edward M.
Wellington, Cheryl L.
Sekhon, Mypinder S.
The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19
title The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19
title_full The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19
title_fullStr The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19
title_full_unstemmed The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19
title_short The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19
title_sort association of abo blood group with indices of disease severity and multiorgan dysfunction in covid-19
topic Clinical Trials and Observations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594392/
https://www.ncbi.nlm.nih.gov/pubmed/33057633
http://dx.doi.org/10.1182/bloodadvances.2020002623
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