Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice

BACKGROUND: Triggering receptor expressed on myeloid cells 2 (TREM2) is expressed in the brain exclusively on microglia and genetic variants are linked to neurodegenerative diseases including Alzheimer’s disease (AD), frontotemporal dementia (FTD) and Nasu Hakola Disease (NHD). The Trem2 variant R47...

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Detalles Bibliográficos
Autores principales: Jadhav, Vaishnavi S., Lin, Peter B. C., Pennington, Taylor, Di Prisco, Gonzalo Viana, Jannu, Asha Jacob, Xu, Guixiang, Moutinho, Miguel, Zhang, Jie, Atwood, Brady K., Puntambekar, Shweta S., Bissel, Stephanie J., Oblak, Adrian L., Landreth, Gary E., Lamb, Bruce T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594478/
https://www.ncbi.nlm.nih.gov/pubmed/33115519
http://dx.doi.org/10.1186/s13024-020-00409-0

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