Cargando…

Glioma surveillance imaging: current strategies, shortcomings, challenges and outlook

Inaccurate assessment of surveillance imaging to assess response to glioma therapy may have life-changing consequences. Varied management plans including chemotherapy, radiotherapy or immunotherapy may all contribute to heterogeneous post-treatment appearances and the overlap between the morphologic...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdalla, Gehad, Hammam, Ahmed, Anjari, Mustafa, D'Arco, Dr. Felice, Bisdas, Dr. Sotirios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594888/
https://www.ncbi.nlm.nih.gov/pubmed/33178973
http://dx.doi.org/10.1259/bjro.20200009
_version_ 1783601722101334016
author Abdalla, Gehad
Hammam, Ahmed
Anjari, Mustafa
D'Arco, Dr. Felice
Bisdas, Dr. Sotirios
author_facet Abdalla, Gehad
Hammam, Ahmed
Anjari, Mustafa
D'Arco, Dr. Felice
Bisdas, Dr. Sotirios
author_sort Abdalla, Gehad
collection PubMed
description Inaccurate assessment of surveillance imaging to assess response to glioma therapy may have life-changing consequences. Varied management plans including chemotherapy, radiotherapy or immunotherapy may all contribute to heterogeneous post-treatment appearances and the overlap between the morphological features of pseudoprogression, pseudoresponse and radiation necrosis can make their discrimination very challenging. Therefore, there has been a drive to develop objective strategies for post-treatment assessment of brain gliomas. This review discusses the most important of these approaches such as the RANO “Response Assessment in Neuro-Oncology”, iRANO “Immunotherapy Response Assessment in Neuro-Oncology” and RAPNO “Response Assessment in Paediatric Neuro-Oncology” models. In addition to these systematic approaches for glioma surveillance, the relatively limited information provided by conventional imaging modalities alone has motivated the development of novel advanced magnetic resonance (MR) and metabolic imaging methods for further discrimination between viable tumour and treatment induced changes. Multiple clinical trials and meta-analyses have investigated the diagnostic performance of these novel techniques in the follow up of brain gliomas, including both single modality descriptive studies and comparative imaging assessment. In this manuscript, we review the literature and discuss the promises and pitfalls of frequently studied modalities in glioma surveillance imaging, including MR perfusion, MR diffusion and MR spectroscopy. In addition, we evaluate other promising MR techniques such as chemical exchange saturation transfer as well as fludeoxyglucose and non-FDG positron emission tomography techniques.
format Online
Article
Text
id pubmed-7594888
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The British Institute of Radiology.
record_format MEDLINE/PubMed
spelling pubmed-75948882020-11-10 Glioma surveillance imaging: current strategies, shortcomings, challenges and outlook Abdalla, Gehad Hammam, Ahmed Anjari, Mustafa D'Arco, Dr. Felice Bisdas, Dr. Sotirios BJR Open Review Article Inaccurate assessment of surveillance imaging to assess response to glioma therapy may have life-changing consequences. Varied management plans including chemotherapy, radiotherapy or immunotherapy may all contribute to heterogeneous post-treatment appearances and the overlap between the morphological features of pseudoprogression, pseudoresponse and radiation necrosis can make their discrimination very challenging. Therefore, there has been a drive to develop objective strategies for post-treatment assessment of brain gliomas. This review discusses the most important of these approaches such as the RANO “Response Assessment in Neuro-Oncology”, iRANO “Immunotherapy Response Assessment in Neuro-Oncology” and RAPNO “Response Assessment in Paediatric Neuro-Oncology” models. In addition to these systematic approaches for glioma surveillance, the relatively limited information provided by conventional imaging modalities alone has motivated the development of novel advanced magnetic resonance (MR) and metabolic imaging methods for further discrimination between viable tumour and treatment induced changes. Multiple clinical trials and meta-analyses have investigated the diagnostic performance of these novel techniques in the follow up of brain gliomas, including both single modality descriptive studies and comparative imaging assessment. In this manuscript, we review the literature and discuss the promises and pitfalls of frequently studied modalities in glioma surveillance imaging, including MR perfusion, MR diffusion and MR spectroscopy. In addition, we evaluate other promising MR techniques such as chemical exchange saturation transfer as well as fludeoxyglucose and non-FDG positron emission tomography techniques. The British Institute of Radiology. 2020-06-23 /pmc/articles/PMC7594888/ /pubmed/33178973 http://dx.doi.org/10.1259/bjro.20200009 Text en © 2020 The Authors. Published by the British Institute of Radiology This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review Article
Abdalla, Gehad
Hammam, Ahmed
Anjari, Mustafa
D'Arco, Dr. Felice
Bisdas, Dr. Sotirios
Glioma surveillance imaging: current strategies, shortcomings, challenges and outlook
title Glioma surveillance imaging: current strategies, shortcomings, challenges and outlook
title_full Glioma surveillance imaging: current strategies, shortcomings, challenges and outlook
title_fullStr Glioma surveillance imaging: current strategies, shortcomings, challenges and outlook
title_full_unstemmed Glioma surveillance imaging: current strategies, shortcomings, challenges and outlook
title_short Glioma surveillance imaging: current strategies, shortcomings, challenges and outlook
title_sort glioma surveillance imaging: current strategies, shortcomings, challenges and outlook
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594888/
https://www.ncbi.nlm.nih.gov/pubmed/33178973
http://dx.doi.org/10.1259/bjro.20200009
work_keys_str_mv AT abdallagehad gliomasurveillanceimagingcurrentstrategiesshortcomingschallengesandoutlook
AT hammamahmed gliomasurveillanceimagingcurrentstrategiesshortcomingschallengesandoutlook
AT anjarimustafa gliomasurveillanceimagingcurrentstrategiesshortcomingschallengesandoutlook
AT darcodrfelice gliomasurveillanceimagingcurrentstrategiesshortcomingschallengesandoutlook
AT bisdasdrsotirios gliomasurveillanceimagingcurrentstrategiesshortcomingschallengesandoutlook