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Do statins play any role in reducing the incidence and mortality of ovarian cancer? A systematic review and meta-analysis

INTRODUCTION: This systematic review and meta-analysis aimed to investigate the relationship between statin consumption and risk of incidence of ovarian cancer (OC) and associated mortality. METHODS: Computerized searches were conducted in three electronic databases (PubMed, Web of Science, and Scop...

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Autores principales: MOHAMMADIAN-HAFSHEJANI, ABDOLLAH, SHERWIN, CATHERINE M.T., HEIDARI-SOURESHJANI, SAEID
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore Srl 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595068/
https://www.ncbi.nlm.nih.gov/pubmed/33150223
http://dx.doi.org/10.15167/2421-4248/jpmh2020.61.3.1497
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author MOHAMMADIAN-HAFSHEJANI, ABDOLLAH
SHERWIN, CATHERINE M.T.
HEIDARI-SOURESHJANI, SAEID
author_facet MOHAMMADIAN-HAFSHEJANI, ABDOLLAH
SHERWIN, CATHERINE M.T.
HEIDARI-SOURESHJANI, SAEID
author_sort MOHAMMADIAN-HAFSHEJANI, ABDOLLAH
collection PubMed
description INTRODUCTION: This systematic review and meta-analysis aimed to investigate the relationship between statin consumption and risk of incidence of ovarian cancer (OC) and associated mortality. METHODS: Computerized searches were conducted in three electronic databases (PubMed, Web of Science, and Scopus). Two calibrated authors performed the publications selection, data extraction, and quality assessment of the selected publications. The quality of the included articles was evaluated using the Newcastle-Ottawa Scale (NOS) for observational studies, and Jadad criteria for randomized clinical trials (RCTs). The electronic searches retrieved 2272 titles/abstracts. After the deletion of duplicate publications, 2030 titles/abstracts were assessed. Eighteen articles were included. RESULTS: Meta-analysis demonstrated that risk ratio (RR) of the association between statin consumption and OC incidence was 0.88 (95% CI = 0.75-1.03, P = 0.109). Patients receiving statin were less likely to die than those who did not receive statin, with a statistically significant association [RR = 0.76 (95% CI 0.67-0.86, P = 0.0001)]. There was no evidence of publication bias in examining the association between statin consumption and the risk of incidence and mortality from OC. CONCLUSIONS: This study determined that statin use reduced the incidence risk of OC and significantly increased the survival in OC patients.
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spelling pubmed-75950682020-11-03 Do statins play any role in reducing the incidence and mortality of ovarian cancer? A systematic review and meta-analysis MOHAMMADIAN-HAFSHEJANI, ABDOLLAH SHERWIN, CATHERINE M.T. HEIDARI-SOURESHJANI, SAEID J Prev Med Hyg Review INTRODUCTION: This systematic review and meta-analysis aimed to investigate the relationship between statin consumption and risk of incidence of ovarian cancer (OC) and associated mortality. METHODS: Computerized searches were conducted in three electronic databases (PubMed, Web of Science, and Scopus). Two calibrated authors performed the publications selection, data extraction, and quality assessment of the selected publications. The quality of the included articles was evaluated using the Newcastle-Ottawa Scale (NOS) for observational studies, and Jadad criteria for randomized clinical trials (RCTs). The electronic searches retrieved 2272 titles/abstracts. After the deletion of duplicate publications, 2030 titles/abstracts were assessed. Eighteen articles were included. RESULTS: Meta-analysis demonstrated that risk ratio (RR) of the association between statin consumption and OC incidence was 0.88 (95% CI = 0.75-1.03, P = 0.109). Patients receiving statin were less likely to die than those who did not receive statin, with a statistically significant association [RR = 0.76 (95% CI 0.67-0.86, P = 0.0001)]. There was no evidence of publication bias in examining the association between statin consumption and the risk of incidence and mortality from OC. CONCLUSIONS: This study determined that statin use reduced the incidence risk of OC and significantly increased the survival in OC patients. Pacini Editore Srl 2020-10-06 /pmc/articles/PMC7595068/ /pubmed/33150223 http://dx.doi.org/10.15167/2421-4248/jpmh2020.61.3.1497 Text en ©2020 Pacini Editore SRL, Pisa, Italy https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en This is an open access article distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International) license. The article can be used by giving appropriate credit and mentioning the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en
spellingShingle Review
MOHAMMADIAN-HAFSHEJANI, ABDOLLAH
SHERWIN, CATHERINE M.T.
HEIDARI-SOURESHJANI, SAEID
Do statins play any role in reducing the incidence and mortality of ovarian cancer? A systematic review and meta-analysis
title Do statins play any role in reducing the incidence and mortality of ovarian cancer? A systematic review and meta-analysis
title_full Do statins play any role in reducing the incidence and mortality of ovarian cancer? A systematic review and meta-analysis
title_fullStr Do statins play any role in reducing the incidence and mortality of ovarian cancer? A systematic review and meta-analysis
title_full_unstemmed Do statins play any role in reducing the incidence and mortality of ovarian cancer? A systematic review and meta-analysis
title_short Do statins play any role in reducing the incidence and mortality of ovarian cancer? A systematic review and meta-analysis
title_sort do statins play any role in reducing the incidence and mortality of ovarian cancer? a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595068/
https://www.ncbi.nlm.nih.gov/pubmed/33150223
http://dx.doi.org/10.15167/2421-4248/jpmh2020.61.3.1497
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