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YAP and TAZ protect against white adipocyte cell death during obesity
The expansion of the white adipose tissue (WAT) in obesity goes along with increased mechanical, metabolic and inflammatory stress. How adipocytes resist this stress is still poorly understood. Both in human and mouse adipocytes, the transcriptional co-activators YAP/TAZ and YAP/TAZ target genes bec...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595161/ https://www.ncbi.nlm.nih.gov/pubmed/33116140 http://dx.doi.org/10.1038/s41467-020-19229-3 |
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author | Wang, Lei Wang, ShengPeng Shi, Yue Li, Rui Günther, Stefan Ong, Yu Ting Potente, Michael Yuan, Zuyi Liu, Enqi Offermanns, Stefan |
author_facet | Wang, Lei Wang, ShengPeng Shi, Yue Li, Rui Günther, Stefan Ong, Yu Ting Potente, Michael Yuan, Zuyi Liu, Enqi Offermanns, Stefan |
author_sort | Wang, Lei |
collection | PubMed |
description | The expansion of the white adipose tissue (WAT) in obesity goes along with increased mechanical, metabolic and inflammatory stress. How adipocytes resist this stress is still poorly understood. Both in human and mouse adipocytes, the transcriptional co-activators YAP/TAZ and YAP/TAZ target genes become activated during obesity. When fed a high-fat diet (HFD), mice lacking YAP/TAZ in white adipocytes develop severe lipodystrophy with adipocyte cell death. The pro-apoptotic factor BIM, which is downregulated in adipocytes of obese mice and humans, is strongly upregulated in YAP/TAZ-deficient adipocytes under HFD, and suppression of BIM expression reduces adipocyte apoptosis. In differentiated adipocytes, TNFα and IL-1β promote YAP/TAZ nuclear translocation via activation of RhoA-mediated actomyosin contractility and increase YAP/TAZ-mediated transcriptional regulation by activation of c-Jun N-terminal kinase (JNK) and AP-1. Our data indicate that the YAP/TAZ signaling pathway may be a target to control adipocyte cell death and compensatory adipogenesis during obesity. |
format | Online Article Text |
id | pubmed-7595161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-75951612020-11-10 YAP and TAZ protect against white adipocyte cell death during obesity Wang, Lei Wang, ShengPeng Shi, Yue Li, Rui Günther, Stefan Ong, Yu Ting Potente, Michael Yuan, Zuyi Liu, Enqi Offermanns, Stefan Nat Commun Article The expansion of the white adipose tissue (WAT) in obesity goes along with increased mechanical, metabolic and inflammatory stress. How adipocytes resist this stress is still poorly understood. Both in human and mouse adipocytes, the transcriptional co-activators YAP/TAZ and YAP/TAZ target genes become activated during obesity. When fed a high-fat diet (HFD), mice lacking YAP/TAZ in white adipocytes develop severe lipodystrophy with adipocyte cell death. The pro-apoptotic factor BIM, which is downregulated in adipocytes of obese mice and humans, is strongly upregulated in YAP/TAZ-deficient adipocytes under HFD, and suppression of BIM expression reduces adipocyte apoptosis. In differentiated adipocytes, TNFα and IL-1β promote YAP/TAZ nuclear translocation via activation of RhoA-mediated actomyosin contractility and increase YAP/TAZ-mediated transcriptional regulation by activation of c-Jun N-terminal kinase (JNK) and AP-1. Our data indicate that the YAP/TAZ signaling pathway may be a target to control adipocyte cell death and compensatory adipogenesis during obesity. Nature Publishing Group UK 2020-10-28 /pmc/articles/PMC7595161/ /pubmed/33116140 http://dx.doi.org/10.1038/s41467-020-19229-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wang, Lei Wang, ShengPeng Shi, Yue Li, Rui Günther, Stefan Ong, Yu Ting Potente, Michael Yuan, Zuyi Liu, Enqi Offermanns, Stefan YAP and TAZ protect against white adipocyte cell death during obesity |
title | YAP and TAZ protect against white adipocyte cell death during obesity |
title_full | YAP and TAZ protect against white adipocyte cell death during obesity |
title_fullStr | YAP and TAZ protect against white adipocyte cell death during obesity |
title_full_unstemmed | YAP and TAZ protect against white adipocyte cell death during obesity |
title_short | YAP and TAZ protect against white adipocyte cell death during obesity |
title_sort | yap and taz protect against white adipocyte cell death during obesity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595161/ https://www.ncbi.nlm.nih.gov/pubmed/33116140 http://dx.doi.org/10.1038/s41467-020-19229-3 |
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