Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma

CDK4/6 inhibitors show promising antitumor activity in a variety of solid tumors; however, their role in head and neck squamous cell carcinoma (HNSCC) requires further investigation. The senescence-associated secretory phenotype (SASP) induced by CDK4/6 inhibitors has dual effects on cancer treatmen...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Qinchao, Peng, Jianmin, Jiang, Laibo, Li, Wuguo, Su, Qiao, Zhang, Jiayu, Li, Huan, Song, Ming, Cheng, Bin, Xia, Juan, Wu, Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595194/
https://www.ncbi.nlm.nih.gov/pubmed/33116117
http://dx.doi.org/10.1038/s41419-020-03126-0

Ejemplares similares

Ejemplares similares