Cargando…
Time to first treatment and P53 dysfunction in chronic lymphocytic leukaemia: results of the O-CLL1 study in early stage patients
Chronic lymphocytic leukaemia (CLL) is characterised by a heterogeneous clinical course. Such heterogeneity is associated with a number of markers, including TP53 gene inactivation. While TP53 gene alterations determine resistance to chemotherapy, it is not clear whether they can influence early dis...
Autores principales: | Monti, Paola, Lionetti, Marta, De Luca, Giuseppa, Menichini, Paola, Recchia, Anna Grazia, Matis, Serena, Colombo, Monica, Fabris, Sonia, Speciale, Andrea, Barbieri, Marzia, Gentile, Massimo, Zupo, Simonetta, Dono, Mariella, Ibatici, Adalberto, Neri, Antonino, Ferrarini, Manlio, Fais, Franco, Fronza, Gilberto, Cutrona, Giovanna, Morabito, Fortunato |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595214/ https://www.ncbi.nlm.nih.gov/pubmed/33116240 http://dx.doi.org/10.1038/s41598-020-75364-3 |
Ejemplares similares
-
The spectrum of subclonal TP53 mutations in chronic lymphocytic leukemia: A next generation sequencing retrospective study
por: De Luca, Giuseppa, et al.
Publicado: (2022) -
Antitumor Effects of PRIMA-1 and PRIMA-1(Met) (APR246) in Hematological Malignancies: Still a Mutant P53-Dependent Affair?
por: Menichini, Paola, et al.
Publicado: (2021) -
Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?
por: Monti, Paola, et al.
Publicado: (2020) -
MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells
por: Matis, Serena, et al.
Publicado: (2022) -
NEAT1 Long Isoform Is Highly Expressed in Chronic Lymphocytic Leukemia Irrespectively of Cytogenetic Groups or Clinical Outcome
por: Ronchetti, Domenica, et al.
Publicado: (2020)