Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

Adeno-associated virus (AAV) forms the basis for several commercial gene therapy products and for countless gene transfer vectors derived from natural or synthetic viral isolates that are under intense preclinical evaluation. Here, we report a versatile pipeline that enables the direct side-by-side...

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Detalles Bibliográficos
Autores principales: Weinmann, Jonas, Weis, Sabrina, Sippel, Josefine, Tulalamba, Warut, Remes, Anca, El Andari, Jihad, Herrmann, Anne-Kathrin, Pham, Quang H., Borowski, Christopher, Hille, Susanne, Schönberger, Tanja, Frey, Norbert, Lenter, Martin, VandenDriessche, Thierry, Müller, Oliver J., Chuah, Marinee K., Lamla, Thorsten, Grimm, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595228/
https://www.ncbi.nlm.nih.gov/pubmed/33116134
http://dx.doi.org/10.1038/s41467-020-19230-w

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