Cargando…

Microbiological and Clinical evaluation of Neem gel and Chlorhexidine gel on Dental Plaque and Gingivitis in 20-30 Years Old Adults: A Randomized Parallel-Armed, Double-Blinded Controlled Trial

BACKGROUND: The etiological relationship between the plaque and the gingival inflammation has been long established. The long-term use of chemical antiplaque agents may lead to side effects such as teeth staining and alteration of taste. Therefore, natural plant extracts with potential antibacterial...

Descripción completa

Detalles Bibliográficos
Autores principales: Nimbulkar, Gargi, Garacha, Vikram, Shetty, Vittaldas, Bhor, Ketaki, Srivastava, Kumar Chandan, Shrivastava, Deepti, Sghaireen, Mohammed G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595480/
https://www.ncbi.nlm.nih.gov/pubmed/33149484
http://dx.doi.org/10.4103/jpbs.JPBS_101_20
_version_ 1783601884277243904
author Nimbulkar, Gargi
Garacha, Vikram
Shetty, Vittaldas
Bhor, Ketaki
Srivastava, Kumar Chandan
Shrivastava, Deepti
Sghaireen, Mohammed G
author_facet Nimbulkar, Gargi
Garacha, Vikram
Shetty, Vittaldas
Bhor, Ketaki
Srivastava, Kumar Chandan
Shrivastava, Deepti
Sghaireen, Mohammed G
author_sort Nimbulkar, Gargi
collection PubMed
description BACKGROUND: The etiological relationship between the plaque and the gingival inflammation has been long established. The long-term use of chemical antiplaque agents may lead to side effects such as teeth staining and alteration of taste. Therefore, natural plant extracts with potential antibacterial and anti-inflammatory activity have been explored, which are equally effective and safe for long-term use. OBJECTIVE: The aim of this study was to compare and evaluate effect of neem gel and chlorhexidine (CHX) gel on dental plaque, gingivitis, and bacterial count of Streptococcus mutans and Lactobacilli among 20–30-year-old school teachers in a city of western Maharashtra, over 90 days’ usage. MATERIALS AND METHODS: A double-blind, parallel armed, controlled, randomized clinical study was conducted among 60 school teachers of 20–30 years’ age group for 90 days. The two study groups were as follows: Group A––2.5% neem gel (n = 30) and Group B––0.2% CHX gel (n = 30). The plaque scores were recorded by Plaque Index (Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967;38:610-6) and gingival scores by Gingival Index (Löe H, Silness J. Periodontal disease in pregnancy. Acta Odontol Scand 1963;21:533-51). Streptococcus mutans and Lactobacilli species count by conventional culture method was carried out at baseline, 30th day and 90thday. Considering P value <0.05 as statistically significant, intergroup comparison was performed using unpaired t test. One-way analysis of variance (ANOVA) test was used followed by Tukey’s post hoc test for intragroup comparison. RESULTS: The mean plaque, gingival scores, and microbial count of S. mutans and Lactobacilli showed significant reduction at 30th and 90th day in neem gel group as well as CHX gel group (P < 0.05). None of the parameter showed any significant change at 30th and 90th day (P > 0.05) on intergroup comparison. CONCLUSION: The neem gel showed significant decrease in dental plaque, gingival inflammation, and microbial counts, which was comparable to CHX gel proving to be a good herbal alternative. No side effects were reported for use of neem gel over considered period of time.
format Online
Article
Text
id pubmed-7595480
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-75954802020-11-03 Microbiological and Clinical evaluation of Neem gel and Chlorhexidine gel on Dental Plaque and Gingivitis in 20-30 Years Old Adults: A Randomized Parallel-Armed, Double-Blinded Controlled Trial Nimbulkar, Gargi Garacha, Vikram Shetty, Vittaldas Bhor, Ketaki Srivastava, Kumar Chandan Shrivastava, Deepti Sghaireen, Mohammed G J Pharm Bioallied Sci Original Article BACKGROUND: The etiological relationship between the plaque and the gingival inflammation has been long established. The long-term use of chemical antiplaque agents may lead to side effects such as teeth staining and alteration of taste. Therefore, natural plant extracts with potential antibacterial and anti-inflammatory activity have been explored, which are equally effective and safe for long-term use. OBJECTIVE: The aim of this study was to compare and evaluate effect of neem gel and chlorhexidine (CHX) gel on dental plaque, gingivitis, and bacterial count of Streptococcus mutans and Lactobacilli among 20–30-year-old school teachers in a city of western Maharashtra, over 90 days’ usage. MATERIALS AND METHODS: A double-blind, parallel armed, controlled, randomized clinical study was conducted among 60 school teachers of 20–30 years’ age group for 90 days. The two study groups were as follows: Group A––2.5% neem gel (n = 30) and Group B––0.2% CHX gel (n = 30). The plaque scores were recorded by Plaque Index (Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967;38:610-6) and gingival scores by Gingival Index (Löe H, Silness J. Periodontal disease in pregnancy. Acta Odontol Scand 1963;21:533-51). Streptococcus mutans and Lactobacilli species count by conventional culture method was carried out at baseline, 30th day and 90thday. Considering P value <0.05 as statistically significant, intergroup comparison was performed using unpaired t test. One-way analysis of variance (ANOVA) test was used followed by Tukey’s post hoc test for intragroup comparison. RESULTS: The mean plaque, gingival scores, and microbial count of S. mutans and Lactobacilli showed significant reduction at 30th and 90th day in neem gel group as well as CHX gel group (P < 0.05). None of the parameter showed any significant change at 30th and 90th day (P > 0.05) on intergroup comparison. CONCLUSION: The neem gel showed significant decrease in dental plaque, gingival inflammation, and microbial counts, which was comparable to CHX gel proving to be a good herbal alternative. No side effects were reported for use of neem gel over considered period of time. Wolters Kluwer - Medknow 2020-08 2020-08-28 /pmc/articles/PMC7595480/ /pubmed/33149484 http://dx.doi.org/10.4103/jpbs.JPBS_101_20 Text en Copyright: © 2020 Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Nimbulkar, Gargi
Garacha, Vikram
Shetty, Vittaldas
Bhor, Ketaki
Srivastava, Kumar Chandan
Shrivastava, Deepti
Sghaireen, Mohammed G
Microbiological and Clinical evaluation of Neem gel and Chlorhexidine gel on Dental Plaque and Gingivitis in 20-30 Years Old Adults: A Randomized Parallel-Armed, Double-Blinded Controlled Trial
title Microbiological and Clinical evaluation of Neem gel and Chlorhexidine gel on Dental Plaque and Gingivitis in 20-30 Years Old Adults: A Randomized Parallel-Armed, Double-Blinded Controlled Trial
title_full Microbiological and Clinical evaluation of Neem gel and Chlorhexidine gel on Dental Plaque and Gingivitis in 20-30 Years Old Adults: A Randomized Parallel-Armed, Double-Blinded Controlled Trial
title_fullStr Microbiological and Clinical evaluation of Neem gel and Chlorhexidine gel on Dental Plaque and Gingivitis in 20-30 Years Old Adults: A Randomized Parallel-Armed, Double-Blinded Controlled Trial
title_full_unstemmed Microbiological and Clinical evaluation of Neem gel and Chlorhexidine gel on Dental Plaque and Gingivitis in 20-30 Years Old Adults: A Randomized Parallel-Armed, Double-Blinded Controlled Trial
title_short Microbiological and Clinical evaluation of Neem gel and Chlorhexidine gel on Dental Plaque and Gingivitis in 20-30 Years Old Adults: A Randomized Parallel-Armed, Double-Blinded Controlled Trial
title_sort microbiological and clinical evaluation of neem gel and chlorhexidine gel on dental plaque and gingivitis in 20-30 years old adults: a randomized parallel-armed, double-blinded controlled trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595480/
https://www.ncbi.nlm.nih.gov/pubmed/33149484
http://dx.doi.org/10.4103/jpbs.JPBS_101_20
work_keys_str_mv AT nimbulkargargi microbiologicalandclinicalevaluationofneemgelandchlorhexidinegelondentalplaqueandgingivitisin2030yearsoldadultsarandomizedparallelarmeddoubleblindedcontrolledtrial
AT garachavikram microbiologicalandclinicalevaluationofneemgelandchlorhexidinegelondentalplaqueandgingivitisin2030yearsoldadultsarandomizedparallelarmeddoubleblindedcontrolledtrial
AT shettyvittaldas microbiologicalandclinicalevaluationofneemgelandchlorhexidinegelondentalplaqueandgingivitisin2030yearsoldadultsarandomizedparallelarmeddoubleblindedcontrolledtrial
AT bhorketaki microbiologicalandclinicalevaluationofneemgelandchlorhexidinegelondentalplaqueandgingivitisin2030yearsoldadultsarandomizedparallelarmeddoubleblindedcontrolledtrial
AT srivastavakumarchandan microbiologicalandclinicalevaluationofneemgelandchlorhexidinegelondentalplaqueandgingivitisin2030yearsoldadultsarandomizedparallelarmeddoubleblindedcontrolledtrial
AT shrivastavadeepti microbiologicalandclinicalevaluationofneemgelandchlorhexidinegelondentalplaqueandgingivitisin2030yearsoldadultsarandomizedparallelarmeddoubleblindedcontrolledtrial
AT sghaireenmohammedg microbiologicalandclinicalevaluationofneemgelandchlorhexidinegelondentalplaqueandgingivitisin2030yearsoldadultsarandomizedparallelarmeddoubleblindedcontrolledtrial