Bone Sparing Effects of Bisphosphonates in Cyclosporine-induced Alveolar Bone Loss: An Animal Study

Various pharmacological agents are known to create an imbalance in the normal physiology of bone remodeling. Cyclosporine-A (Cs-A) is one of the drugs that is widely used in transplantation and has its main side effect as gingival hyperplasia and alveolar bone loss by their action on the inflammator...

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Autores principales: Bhat, Sneha R, Shwetha, Rajanna, Boloor, Vinita A, Kini, Shravan R, Kudva, Aravind R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595528/
https://www.ncbi.nlm.nih.gov/pubmed/33149521
http://dx.doi.org/10.4103/jpbs.JPBS_171_20
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author Bhat, Sneha R
Shwetha, Rajanna
Boloor, Vinita A
Kini, Shravan R
Kudva, Aravind R
author_facet Bhat, Sneha R
Shwetha, Rajanna
Boloor, Vinita A
Kini, Shravan R
Kudva, Aravind R
author_sort Bhat, Sneha R
collection PubMed
description Various pharmacological agents are known to create an imbalance in the normal physiology of bone remodeling. Cyclosporine-A (Cs-A) is one of the drugs that is widely used in transplantation and has its main side effect as gingival hyperplasia and alveolar bone loss by their action on the inflammatory mediators. Bisphosphonates are a new class of drugs that inhibit bone resorption by decreasing the osteoclast activity and number. The aim of this study was to evaluate the effect of concomitant administration of alendronate on Cs-A-induced alveolar bone loss in a rat model.
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spelling pubmed-75955282020-11-03 Bone Sparing Effects of Bisphosphonates in Cyclosporine-induced Alveolar Bone Loss: An Animal Study Bhat, Sneha R Shwetha, Rajanna Boloor, Vinita A Kini, Shravan R Kudva, Aravind R J Pharm Bioallied Sci Original Article Various pharmacological agents are known to create an imbalance in the normal physiology of bone remodeling. Cyclosporine-A (Cs-A) is one of the drugs that is widely used in transplantation and has its main side effect as gingival hyperplasia and alveolar bone loss by their action on the inflammatory mediators. Bisphosphonates are a new class of drugs that inhibit bone resorption by decreasing the osteoclast activity and number. The aim of this study was to evaluate the effect of concomitant administration of alendronate on Cs-A-induced alveolar bone loss in a rat model. Wolters Kluwer - Medknow 2020-08 2020-08-28 /pmc/articles/PMC7595528/ /pubmed/33149521 http://dx.doi.org/10.4103/jpbs.JPBS_171_20 Text en Copyright: © 2020 Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Bhat, Sneha R
Shwetha, Rajanna
Boloor, Vinita A
Kini, Shravan R
Kudva, Aravind R
Bone Sparing Effects of Bisphosphonates in Cyclosporine-induced Alveolar Bone Loss: An Animal Study
title Bone Sparing Effects of Bisphosphonates in Cyclosporine-induced Alveolar Bone Loss: An Animal Study
title_full Bone Sparing Effects of Bisphosphonates in Cyclosporine-induced Alveolar Bone Loss: An Animal Study
title_fullStr Bone Sparing Effects of Bisphosphonates in Cyclosporine-induced Alveolar Bone Loss: An Animal Study
title_full_unstemmed Bone Sparing Effects of Bisphosphonates in Cyclosporine-induced Alveolar Bone Loss: An Animal Study
title_short Bone Sparing Effects of Bisphosphonates in Cyclosporine-induced Alveolar Bone Loss: An Animal Study
title_sort bone sparing effects of bisphosphonates in cyclosporine-induced alveolar bone loss: an animal study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595528/
https://www.ncbi.nlm.nih.gov/pubmed/33149521
http://dx.doi.org/10.4103/jpbs.JPBS_171_20
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