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Evaluation of Alteration in Oral Microbial Flora Pre- and Postradiation Therapy in Patients with Head and Neck Cancer

INTRODUCTION: For decades now, head and neck cancer (HNC) remains to be one of the deadliest; per se the treatment for the same has been evolving for the past years. Radiation therapy (RT) has been one among the various treatment modalities adopted to treat HNC. The fact that RT can affect the quali...

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Autores principales: Priya, Ayanambakkam Hemasundar Harini, Rajmohan, Arun Kumar, Hari Priya, Akash Raj, Shakthi, Archana, Sai, Venkatanarasu, Bharathwaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595542/
https://www.ncbi.nlm.nih.gov/pubmed/33149440
http://dx.doi.org/10.4103/jpbs.JPBS_38_20
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author Priya, Ayanambakkam Hemasundar Harini
Rajmohan,
Arun Kumar, Hari Priya
Akash Raj, Shakthi
Archana, Sai
Venkatanarasu, Bharathwaj
author_facet Priya, Ayanambakkam Hemasundar Harini
Rajmohan,
Arun Kumar, Hari Priya
Akash Raj, Shakthi
Archana, Sai
Venkatanarasu, Bharathwaj
author_sort Priya, Ayanambakkam Hemasundar Harini
collection PubMed
description INTRODUCTION: For decades now, head and neck cancer (HNC) remains to be one of the deadliest; per se the treatment for the same has been evolving for the past years. Radiation therapy (RT) has been one among the various treatment modalities adopted to treat HNC. The fact that RT can affect the quality of life in these patients cannot be denied. In patients with HNC, these can bring about a wide array of lesions in oral cavity and its associated structures as these areas are invariably affected due to exposure to radiation as such. These include alteration in salivary parameters, changes in microbial flora, and occurrence of radiation caries. AIM: In our study we aimed at assessing the alteration in oral microbial flora inclusive of Streptococcus mutans and Lactobacillus colony count before and after RT. MATERIALS AND METHODS: Saliva and plaque samples were collected from patients with HNC, who were prescribed to undergo intensity-modulated radiation therapy (IMRT) amounting to a mean radiation dosage of 60 Gy units. The aforementioned samples were collected at three different intervals, before, immediately after, and 6 months after RT. The samples were cultured in selective media in three different dilutions (1:10, 1:100, and 1:1000). Following with colony counting is carried out using a standardized colony counter. CONCLUSION: The results showed a significant alteration in microbial flora pre- and post-RT. Individual parameters do not show a single stand in causing these changes. Moreover, these changes seem to have earned a multifactorial contribution.
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spelling pubmed-75955422020-11-03 Evaluation of Alteration in Oral Microbial Flora Pre- and Postradiation Therapy in Patients with Head and Neck Cancer Priya, Ayanambakkam Hemasundar Harini Rajmohan, Arun Kumar, Hari Priya Akash Raj, Shakthi Archana, Sai Venkatanarasu, Bharathwaj J Pharm Bioallied Sci Original Article INTRODUCTION: For decades now, head and neck cancer (HNC) remains to be one of the deadliest; per se the treatment for the same has been evolving for the past years. Radiation therapy (RT) has been one among the various treatment modalities adopted to treat HNC. The fact that RT can affect the quality of life in these patients cannot be denied. In patients with HNC, these can bring about a wide array of lesions in oral cavity and its associated structures as these areas are invariably affected due to exposure to radiation as such. These include alteration in salivary parameters, changes in microbial flora, and occurrence of radiation caries. AIM: In our study we aimed at assessing the alteration in oral microbial flora inclusive of Streptococcus mutans and Lactobacillus colony count before and after RT. MATERIALS AND METHODS: Saliva and plaque samples were collected from patients with HNC, who were prescribed to undergo intensity-modulated radiation therapy (IMRT) amounting to a mean radiation dosage of 60 Gy units. The aforementioned samples were collected at three different intervals, before, immediately after, and 6 months after RT. The samples were cultured in selective media in three different dilutions (1:10, 1:100, and 1:1000). Following with colony counting is carried out using a standardized colony counter. CONCLUSION: The results showed a significant alteration in microbial flora pre- and post-RT. Individual parameters do not show a single stand in causing these changes. Moreover, these changes seem to have earned a multifactorial contribution. Wolters Kluwer - Medknow 2020-08 2020-08-28 /pmc/articles/PMC7595542/ /pubmed/33149440 http://dx.doi.org/10.4103/jpbs.JPBS_38_20 Text en Copyright: © 2020 Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Priya, Ayanambakkam Hemasundar Harini
Rajmohan,
Arun Kumar, Hari Priya
Akash Raj, Shakthi
Archana, Sai
Venkatanarasu, Bharathwaj
Evaluation of Alteration in Oral Microbial Flora Pre- and Postradiation Therapy in Patients with Head and Neck Cancer
title Evaluation of Alteration in Oral Microbial Flora Pre- and Postradiation Therapy in Patients with Head and Neck Cancer
title_full Evaluation of Alteration in Oral Microbial Flora Pre- and Postradiation Therapy in Patients with Head and Neck Cancer
title_fullStr Evaluation of Alteration in Oral Microbial Flora Pre- and Postradiation Therapy in Patients with Head and Neck Cancer
title_full_unstemmed Evaluation of Alteration in Oral Microbial Flora Pre- and Postradiation Therapy in Patients with Head and Neck Cancer
title_short Evaluation of Alteration in Oral Microbial Flora Pre- and Postradiation Therapy in Patients with Head and Neck Cancer
title_sort evaluation of alteration in oral microbial flora pre- and postradiation therapy in patients with head and neck cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595542/
https://www.ncbi.nlm.nih.gov/pubmed/33149440
http://dx.doi.org/10.4103/jpbs.JPBS_38_20
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