Evaluation of Antimicrobial Efficacy of Calcium Hydroxide along with Proton Pump Inhibitor against Enterococcus Faecalis

AIM: The aim of this study was to evaluate in vitro the efficacy of pantoprazole, a proton pump inhibitor, alone, and in combination with calcium hydroxide against Enterococcus faecalis, a star survivor in endodontic pathology. MATERIALS AND METHODS: Teeth were inoculated with E. faecalis strains MT...

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Detalles Bibliográficos
Autores principales: Divakar, Namitha, Mohan, Sunil Paramel, Pulyodan, Manoj Kumar, Tom, Arun, Karukayil, Deepthi, Somasundaram, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595555/
https://www.ncbi.nlm.nih.gov/pubmed/33149485
http://dx.doi.org/10.4103/jpbs.JPBS_104_20
Descripción
Sumario:AIM: The aim of this study was to evaluate in vitro the efficacy of pantoprazole, a proton pump inhibitor, alone, and in combination with calcium hydroxide against Enterococcus faecalis, a star survivor in endodontic pathology. MATERIALS AND METHODS: Teeth were inoculated with E. faecalis strains MTCC 439 and were divided into groups. Group 1 used saline as the negative control, Group 2 used calcium hydroxide, Group 3 used pantoprazole alone, and Group 4 used calcium hydroxide along with pantoprazole. They were incubated and dentine harvesting was performed. Colonies were counted using a digital counting machine. Data were statistically analyzed. RESULTS: Group 4 was found to be the most effective against the pathogen. DISCUSSION: This study indicates that the association of calcium hydroxide with the proton pump inhibitor pantoprazole can be successfully used as an intracanal medicament against E. faecalis.

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