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Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria
Gastrointestinal (GI) diseases, and in particular those caused by bacterial infections, are a major cause of morbidity and mortality worldwide. Treatment is becoming increasingly difficult due to the increase in number of species that have developed resistance to antibiotics. Probiotic lactic acid b...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595611/ https://www.ncbi.nlm.nih.gov/pubmed/33112695 http://dx.doi.org/10.1080/19490976.2020.1831339 |
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author | van Zyl, Winschau F. Deane, Shelly M. Dicks, Leon M.T. |
author_facet | van Zyl, Winschau F. Deane, Shelly M. Dicks, Leon M.T. |
author_sort | van Zyl, Winschau F. |
collection | PubMed |
description | Gastrointestinal (GI) diseases, and in particular those caused by bacterial infections, are a major cause of morbidity and mortality worldwide. Treatment is becoming increasingly difficult due to the increase in number of species that have developed resistance to antibiotics. Probiotic lactic acid bacteria (LAB) have considerable potential as alternatives to antibiotics, both in prophylactic and therapeutic applications. Several studies have documented a reduction, or prevention, of GI diseases by probiotic bacteria. Since the activities of probiotic bacteria are closely linked with conditions in the host’s GI-tract (GIT) and changes in the population of enteric microorganisms, a deeper understanding of gut-microbial interactions is required in the selection of the most suitable probiotic. This necessitates a deeper understanding of the molecular capabilities of probiotic bacteria. In this review, we explore how probiotic microorganisms interact with enteric pathogens in the GIT. The significance of probiotic colonization and persistence in the GIT is also addressed. |
format | Online Article Text |
id | pubmed-7595611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-75956112020-11-10 Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria van Zyl, Winschau F. Deane, Shelly M. Dicks, Leon M.T. Gut Microbes Review Gastrointestinal (GI) diseases, and in particular those caused by bacterial infections, are a major cause of morbidity and mortality worldwide. Treatment is becoming increasingly difficult due to the increase in number of species that have developed resistance to antibiotics. Probiotic lactic acid bacteria (LAB) have considerable potential as alternatives to antibiotics, both in prophylactic and therapeutic applications. Several studies have documented a reduction, or prevention, of GI diseases by probiotic bacteria. Since the activities of probiotic bacteria are closely linked with conditions in the host’s GI-tract (GIT) and changes in the population of enteric microorganisms, a deeper understanding of gut-microbial interactions is required in the selection of the most suitable probiotic. This necessitates a deeper understanding of the molecular capabilities of probiotic bacteria. In this review, we explore how probiotic microorganisms interact with enteric pathogens in the GIT. The significance of probiotic colonization and persistence in the GIT is also addressed. Taylor & Francis 2020-10-28 /pmc/articles/PMC7595611/ /pubmed/33112695 http://dx.doi.org/10.1080/19490976.2020.1831339 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review van Zyl, Winschau F. Deane, Shelly M. Dicks, Leon M.T. Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria |
title | Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria |
title_full | Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria |
title_fullStr | Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria |
title_full_unstemmed | Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria |
title_short | Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria |
title_sort | molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595611/ https://www.ncbi.nlm.nih.gov/pubmed/33112695 http://dx.doi.org/10.1080/19490976.2020.1831339 |
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