Evaluation on the separated effect of 13 hemoglobin variants by a new automatic Hba1c analyzer

OBJECTIVE: To evaluate the effect of a new type of automatic glycated hemoglobin analyzer on the separation of abnormal hemoglobin. METHODS: Samples diagnosed as hemoglobin variants by capillary electrophoresis and gene testing were selected, and HbA1c analyzer was used for separation and detection....

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Detalles Bibliográficos
Autores principales: Li, Rui, Tang, Huamei, Kan, Lijuan, Xiong, Dan, Cheng, Xuedi, Xu, Yan, Liu, Xiancheng, Zhang, Xiuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595897/
https://www.ncbi.nlm.nih.gov/pubmed/32656855
http://dx.doi.org/10.1002/jcla.23446
Descripción
Sumario:OBJECTIVE: To evaluate the effect of a new type of automatic glycated hemoglobin analyzer on the separation of abnormal hemoglobin. METHODS: Samples diagnosed as hemoglobin variants by capillary electrophoresis and gene testing were selected, and HbA1c analyzer was used for separation and detection. RESULTS: A total of 13 hemoglobin variants in 40 samples could be separated from the normal peaks. CONCLUSIONS: The variant mode of hemoglobin HbA1c can identify a variety of hemoglobin variants, and the type of variants can be preliminarily determined according to the retention time and characteristic peak shape of the variants.

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