Evaluation on the separated effect of 13 hemoglobin variants by a new automatic Hba1c analyzer

OBJECTIVE: To evaluate the effect of a new type of automatic glycated hemoglobin analyzer on the separation of abnormal hemoglobin. METHODS: Samples diagnosed as hemoglobin variants by capillary electrophoresis and gene testing were selected, and HbA1c analyzer was used for separation and detection....

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Autores principales: Li, Rui, Tang, Huamei, Kan, Lijuan, Xiong, Dan, Cheng, Xuedi, Xu, Yan, Liu, Xiancheng, Zhang, Xiuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595897/
https://www.ncbi.nlm.nih.gov/pubmed/32656855
http://dx.doi.org/10.1002/jcla.23446
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author Li, Rui
Tang, Huamei
Kan, Lijuan
Xiong, Dan
Cheng, Xuedi
Xu, Yan
Liu, Xiancheng
Zhang, Xiuming
author_facet Li, Rui
Tang, Huamei
Kan, Lijuan
Xiong, Dan
Cheng, Xuedi
Xu, Yan
Liu, Xiancheng
Zhang, Xiuming
author_sort Li, Rui
collection PubMed
description OBJECTIVE: To evaluate the effect of a new type of automatic glycated hemoglobin analyzer on the separation of abnormal hemoglobin. METHODS: Samples diagnosed as hemoglobin variants by capillary electrophoresis and gene testing were selected, and HbA1c analyzer was used for separation and detection. RESULTS: A total of 13 hemoglobin variants in 40 samples could be separated from the normal peaks. CONCLUSIONS: The variant mode of hemoglobin HbA1c can identify a variety of hemoglobin variants, and the type of variants can be preliminarily determined according to the retention time and characteristic peak shape of the variants.
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spelling pubmed-75958972020-11-02 Evaluation on the separated effect of 13 hemoglobin variants by a new automatic Hba1c analyzer Li, Rui Tang, Huamei Kan, Lijuan Xiong, Dan Cheng, Xuedi Xu, Yan Liu, Xiancheng Zhang, Xiuming J Clin Lab Anal Research Articles OBJECTIVE: To evaluate the effect of a new type of automatic glycated hemoglobin analyzer on the separation of abnormal hemoglobin. METHODS: Samples diagnosed as hemoglobin variants by capillary electrophoresis and gene testing were selected, and HbA1c analyzer was used for separation and detection. RESULTS: A total of 13 hemoglobin variants in 40 samples could be separated from the normal peaks. CONCLUSIONS: The variant mode of hemoglobin HbA1c can identify a variety of hemoglobin variants, and the type of variants can be preliminarily determined according to the retention time and characteristic peak shape of the variants. John Wiley and Sons Inc. 2020-07-12 /pmc/articles/PMC7595897/ /pubmed/32656855 http://dx.doi.org/10.1002/jcla.23446 Text en © 2020 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Li, Rui
Tang, Huamei
Kan, Lijuan
Xiong, Dan
Cheng, Xuedi
Xu, Yan
Liu, Xiancheng
Zhang, Xiuming
Evaluation on the separated effect of 13 hemoglobin variants by a new automatic Hba1c analyzer
title Evaluation on the separated effect of 13 hemoglobin variants by a new automatic Hba1c analyzer
title_full Evaluation on the separated effect of 13 hemoglobin variants by a new automatic Hba1c analyzer
title_fullStr Evaluation on the separated effect of 13 hemoglobin variants by a new automatic Hba1c analyzer
title_full_unstemmed Evaluation on the separated effect of 13 hemoglobin variants by a new automatic Hba1c analyzer
title_short Evaluation on the separated effect of 13 hemoglobin variants by a new automatic Hba1c analyzer
title_sort evaluation on the separated effect of 13 hemoglobin variants by a new automatic hba1c analyzer
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595897/
https://www.ncbi.nlm.nih.gov/pubmed/32656855
http://dx.doi.org/10.1002/jcla.23446
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