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Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

OBJECTIVE: The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore, the aim of this study was to determine the role of ferritin...

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Autores principales: Cheng, Linlin, Li, Haolong, Li, Liubing, Liu, Chenxi, Yan, Songxin, Chen, Haizhen, Li, Yongzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595919/
https://www.ncbi.nlm.nih.gov/pubmed/33078400
http://dx.doi.org/10.1002/jcla.23618
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author Cheng, Linlin
Li, Haolong
Li, Liubing
Liu, Chenxi
Yan, Songxin
Chen, Haizhen
Li, Yongzhe
author_facet Cheng, Linlin
Li, Haolong
Li, Liubing
Liu, Chenxi
Yan, Songxin
Chen, Haizhen
Li, Yongzhe
author_sort Cheng, Linlin
collection PubMed
description OBJECTIVE: The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore, the aim of this study was to determine the role of ferritin in COVID‐19. METHODS: Studies investigating ferritin in COVID‐19 were collected from PubMed, EMBASE, CNKI, SinoMed, and WANFANG. A meta‐analysis was performed to compare the ferritin level between different patient groups: non‐survivors versus survivors; more severe versus less severe; with comorbidity versus without comorbidity; ICU versus non‐ICU; with mechanical ventilation versus without mechanical ventilation. RESULTS: A total of 52 records involving 10 614 COVID‐19‐confirmed patients between December 25, 2019, and June 1, 2020, were included in this meta‐analysis, and 18 studies were included in the qualitative synthesis. The ferritin level was significantly increased in severe patients compared with the level in non‐severe patients [WMD 397.77 (95% CI 306.51‐489.02), P < .001]. Non‐survivors had a significantly higher ferritin level compared with the one in survivors [WMD 677.17 (95% CI 391.01‐963.33), P < .001]. Patients with one or more comorbidities including diabetes, thrombotic complication, and cancer had significantly higher levels of ferritin than those without (P < .01). Severe acute liver injury was significantly associated with high levels of ferritin, and its level was associated with intensive supportive care, including ICU transfer and mechanical ventilation. CONCLUSIONS: Ferritin was associated with poor prognosis and could predict the worsening of COVID‐19 patients.
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spelling pubmed-75959192020-11-02 Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis Cheng, Linlin Li, Haolong Li, Liubing Liu, Chenxi Yan, Songxin Chen, Haizhen Li, Yongzhe J Clin Lab Anal Review Article OBJECTIVE: The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore, the aim of this study was to determine the role of ferritin in COVID‐19. METHODS: Studies investigating ferritin in COVID‐19 were collected from PubMed, EMBASE, CNKI, SinoMed, and WANFANG. A meta‐analysis was performed to compare the ferritin level between different patient groups: non‐survivors versus survivors; more severe versus less severe; with comorbidity versus without comorbidity; ICU versus non‐ICU; with mechanical ventilation versus without mechanical ventilation. RESULTS: A total of 52 records involving 10 614 COVID‐19‐confirmed patients between December 25, 2019, and June 1, 2020, were included in this meta‐analysis, and 18 studies were included in the qualitative synthesis. The ferritin level was significantly increased in severe patients compared with the level in non‐severe patients [WMD 397.77 (95% CI 306.51‐489.02), P < .001]. Non‐survivors had a significantly higher ferritin level compared with the one in survivors [WMD 677.17 (95% CI 391.01‐963.33), P < .001]. Patients with one or more comorbidities including diabetes, thrombotic complication, and cancer had significantly higher levels of ferritin than those without (P < .01). Severe acute liver injury was significantly associated with high levels of ferritin, and its level was associated with intensive supportive care, including ICU transfer and mechanical ventilation. CONCLUSIONS: Ferritin was associated with poor prognosis and could predict the worsening of COVID‐19 patients. John Wiley and Sons Inc. 2020-10-19 /pmc/articles/PMC7595919/ /pubmed/33078400 http://dx.doi.org/10.1002/jcla.23618 Text en © 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Article
Cheng, Linlin
Li, Haolong
Li, Liubing
Liu, Chenxi
Yan, Songxin
Chen, Haizhen
Li, Yongzhe
Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
title Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
title_full Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
title_fullStr Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
title_full_unstemmed Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
title_short Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
title_sort ferritin in the coronavirus disease 2019 (covid‐19): a systematic review and meta‐analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595919/
https://www.ncbi.nlm.nih.gov/pubmed/33078400
http://dx.doi.org/10.1002/jcla.23618
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