Drug–Drug Interactions between Direct Oral Anticoagulants and Hepatitis C Direct-Acting Antiviral Agents: Looking for Evidence Through a Systematic Review

BACKGROUND: Direct oral anticoagulants (DOACs), as substrates of cytochrome P450 (CYP) 3A4 and/or P-glycoprotein, are susceptible to drug–drug interactions (DDIs). Hepatitis C direct-acting antiviral agents (DAAs), via P-glycoprotein or CYP3A4 inhibition, may increase DOAC exposure with relevant ble...

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Detalles Bibliográficos
Autores principales: Bellesini, Marta, Bianchin, Matteo, Corradi, Chiara, Donadini, Marco Paolo, Raschi, Emanuel, Squizzato, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Systematic Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595962/
https://www.ncbi.nlm.nih.gov/pubmed/32809123
http://dx.doi.org/10.1007/s40261-020-00962-y

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