Successful treatment of gastric cancer after complete response of lung cancer by nivolumab: a case report

BACKGROUND: Nivolumab is effective for gastric cancer and lung cancer, but complete response is rare. We experienced a case of synchronous gastric cancer and lung cancer who was treated by nivolumab and laparoscopic gastrectomy. CASE PRESENTATION: A 63-year-old male consulted our institution and was...

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Autores principales: Endo, Shunji, Fujiwara, Yoshinori, Kurose, Koji, Higashida, Masaharu, Kubota, Hisako, Okamoto, Yuko, Mineta, Shumei, Tanaka, Hironori, Okada, Toshimasa, Tsuruta, Atsushi, Akiyama, Takashi, Oga, Toru, Ueno, Tomio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596133/
https://www.ncbi.nlm.nih.gov/pubmed/33119806
http://dx.doi.org/10.1186/s40792-020-01053-y
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author Endo, Shunji
Fujiwara, Yoshinori
Kurose, Koji
Higashida, Masaharu
Kubota, Hisako
Okamoto, Yuko
Mineta, Shumei
Tanaka, Hironori
Okada, Toshimasa
Tsuruta, Atsushi
Akiyama, Takashi
Oga, Toru
Ueno, Tomio
author_facet Endo, Shunji
Fujiwara, Yoshinori
Kurose, Koji
Higashida, Masaharu
Kubota, Hisako
Okamoto, Yuko
Mineta, Shumei
Tanaka, Hironori
Okada, Toshimasa
Tsuruta, Atsushi
Akiyama, Takashi
Oga, Toru
Ueno, Tomio
author_sort Endo, Shunji
collection PubMed
description BACKGROUND: Nivolumab is effective for gastric cancer and lung cancer, but complete response is rare. We experienced a case of synchronous gastric cancer and lung cancer who was treated by nivolumab and laparoscopic gastrectomy. CASE PRESENTATION: A 63-year-old male consulted our institution and was found to have gastric cancer cT1(SM)N0M0 Stage IA and lung cancer cT2N2M1(PUL) Stage IV. He received eight chemotherapy treatments plus radiation, but the lung disease remained progressive. Finally, he received nivolumab therapy and complete response of both cancers was obtained. The gastric cancer recurred, but was successfully treated by laparoscopic gastrectomy. The resected specimen revealed three lesions, each being pT1aN0M0 Stage IA. The primary gastric cancer seemed to have completely vanished without scarring. CONCLUSIONS: This was thought to be a rare case of gastric cancer recurrence after complete response of gastric cancer and lung cancer to nivolumab.
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spelling pubmed-75961332020-11-02 Successful treatment of gastric cancer after complete response of lung cancer by nivolumab: a case report Endo, Shunji Fujiwara, Yoshinori Kurose, Koji Higashida, Masaharu Kubota, Hisako Okamoto, Yuko Mineta, Shumei Tanaka, Hironori Okada, Toshimasa Tsuruta, Atsushi Akiyama, Takashi Oga, Toru Ueno, Tomio Surg Case Rep Case Report BACKGROUND: Nivolumab is effective for gastric cancer and lung cancer, but complete response is rare. We experienced a case of synchronous gastric cancer and lung cancer who was treated by nivolumab and laparoscopic gastrectomy. CASE PRESENTATION: A 63-year-old male consulted our institution and was found to have gastric cancer cT1(SM)N0M0 Stage IA and lung cancer cT2N2M1(PUL) Stage IV. He received eight chemotherapy treatments plus radiation, but the lung disease remained progressive. Finally, he received nivolumab therapy and complete response of both cancers was obtained. The gastric cancer recurred, but was successfully treated by laparoscopic gastrectomy. The resected specimen revealed three lesions, each being pT1aN0M0 Stage IA. The primary gastric cancer seemed to have completely vanished without scarring. CONCLUSIONS: This was thought to be a rare case of gastric cancer recurrence after complete response of gastric cancer and lung cancer to nivolumab. Springer Berlin Heidelberg 2020-10-29 /pmc/articles/PMC7596133/ /pubmed/33119806 http://dx.doi.org/10.1186/s40792-020-01053-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Endo, Shunji
Fujiwara, Yoshinori
Kurose, Koji
Higashida, Masaharu
Kubota, Hisako
Okamoto, Yuko
Mineta, Shumei
Tanaka, Hironori
Okada, Toshimasa
Tsuruta, Atsushi
Akiyama, Takashi
Oga, Toru
Ueno, Tomio
Successful treatment of gastric cancer after complete response of lung cancer by nivolumab: a case report
title Successful treatment of gastric cancer after complete response of lung cancer by nivolumab: a case report
title_full Successful treatment of gastric cancer after complete response of lung cancer by nivolumab: a case report
title_fullStr Successful treatment of gastric cancer after complete response of lung cancer by nivolumab: a case report
title_full_unstemmed Successful treatment of gastric cancer after complete response of lung cancer by nivolumab: a case report
title_short Successful treatment of gastric cancer after complete response of lung cancer by nivolumab: a case report
title_sort successful treatment of gastric cancer after complete response of lung cancer by nivolumab: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596133/
https://www.ncbi.nlm.nih.gov/pubmed/33119806
http://dx.doi.org/10.1186/s40792-020-01053-y
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