Chronic Mucocutaneous Candidiasis in Early Life: Insights Into Immune Mechanisms and Novel Targeted Therapies

Children with chronic mucocutaneous candidiasis (CMC) experience recurrent infections with Candida spp. Moreover, immune dysregulation in the early life of these patients induces various autoimmune diseases and affects normal growth and development. The adaptive and innate immune system components p...

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Autores principales: Shamriz, Oded, Tal, Yuval, Talmon, Aviv, Nahum, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596184/
https://www.ncbi.nlm.nih.gov/pubmed/33178226
http://dx.doi.org/10.3389/fimmu.2020.593289
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author Shamriz, Oded
Tal, Yuval
Talmon, Aviv
Nahum, Amit
author_facet Shamriz, Oded
Tal, Yuval
Talmon, Aviv
Nahum, Amit
author_sort Shamriz, Oded
collection PubMed
description Children with chronic mucocutaneous candidiasis (CMC) experience recurrent infections with Candida spp. Moreover, immune dysregulation in the early life of these patients induces various autoimmune diseases and affects normal growth and development. The adaptive and innate immune system components play a significant role in anti-fungal response. This response is mediated through IL-17 production by T helper cells. Inborn errors in IL-17-mediated pathways or Candida spp. sensing molecules are known to cause CMC. In this review, we describe underlying immune mechanisms of monogenic primary immune deficiency disorders known to cause CMC. We will explore insights into current management of these patients and novel available therapies.
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spelling pubmed-75961842020-11-10 Chronic Mucocutaneous Candidiasis in Early Life: Insights Into Immune Mechanisms and Novel Targeted Therapies Shamriz, Oded Tal, Yuval Talmon, Aviv Nahum, Amit Front Immunol Immunology Children with chronic mucocutaneous candidiasis (CMC) experience recurrent infections with Candida spp. Moreover, immune dysregulation in the early life of these patients induces various autoimmune diseases and affects normal growth and development. The adaptive and innate immune system components play a significant role in anti-fungal response. This response is mediated through IL-17 production by T helper cells. Inborn errors in IL-17-mediated pathways or Candida spp. sensing molecules are known to cause CMC. In this review, we describe underlying immune mechanisms of monogenic primary immune deficiency disorders known to cause CMC. We will explore insights into current management of these patients and novel available therapies. Frontiers Media S.A. 2020-10-16 /pmc/articles/PMC7596184/ /pubmed/33178226 http://dx.doi.org/10.3389/fimmu.2020.593289 Text en Copyright © 2020 Shamriz, Tal, Talmon and Nahum. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Shamriz, Oded
Tal, Yuval
Talmon, Aviv
Nahum, Amit
Chronic Mucocutaneous Candidiasis in Early Life: Insights Into Immune Mechanisms and Novel Targeted Therapies
title Chronic Mucocutaneous Candidiasis in Early Life: Insights Into Immune Mechanisms and Novel Targeted Therapies
title_full Chronic Mucocutaneous Candidiasis in Early Life: Insights Into Immune Mechanisms and Novel Targeted Therapies
title_fullStr Chronic Mucocutaneous Candidiasis in Early Life: Insights Into Immune Mechanisms and Novel Targeted Therapies
title_full_unstemmed Chronic Mucocutaneous Candidiasis in Early Life: Insights Into Immune Mechanisms and Novel Targeted Therapies
title_short Chronic Mucocutaneous Candidiasis in Early Life: Insights Into Immune Mechanisms and Novel Targeted Therapies
title_sort chronic mucocutaneous candidiasis in early life: insights into immune mechanisms and novel targeted therapies
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596184/
https://www.ncbi.nlm.nih.gov/pubmed/33178226
http://dx.doi.org/10.3389/fimmu.2020.593289
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