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Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer-related deaths in United States and Europe. It is predicted that PDAC will become the second leading cause of cancer-related deaths during the next decades. The development of PDAC is not well understood, however, stud...

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Autores principales: Schnipper, Julie, Dhennin-Duthille, Isabelle, Ahidouch, Ahmed, Ouadid-Ahidouch, Halima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596276/
https://www.ncbi.nlm.nih.gov/pubmed/33178018
http://dx.doi.org/10.3389/fphar.2020.568993
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author Schnipper, Julie
Dhennin-Duthille, Isabelle
Ahidouch, Ahmed
Ouadid-Ahidouch, Halima
author_facet Schnipper, Julie
Dhennin-Duthille, Isabelle
Ahidouch, Ahmed
Ouadid-Ahidouch, Halima
author_sort Schnipper, Julie
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer-related deaths in United States and Europe. It is predicted that PDAC will become the second leading cause of cancer-related deaths during the next decades. The development of PDAC is not well understood, however, studies have shown that dysregulated exocrine pancreatic fluid secretion can contribute to pathologies of exocrine pancreas, including PDAC. The major roles of healthy exocrine pancreatic tissue are secretion of enzymes and bicarbonate rich fluid, where ion channels participate to fine-tune these biological processes. It is well known that ion channels located in the plasma membrane regulate multiple cellular functions and are involved in the communication between extracellular events and intracellular signaling pathways and can function as signal transducers themselves. Hereby, they contribute to maintain resting membrane potential, electrical signaling in excitable cells, and ion homeostasis. Despite their contribution to basic cellular processes, ion channels are also involved in the malignant transformation from a normal to a malignant phenotype. Aberrant expression and activity of ion channels have an impact on essentially all hallmarks of cancer defined as; uncontrolled proliferation, evasion of apoptosis, sustained angiogenesis and promotion of invasion and migration. Research indicates that certain ion channels are involved in the aberrant tumor growth and metastatic processes of PDAC. The purpose of this review is to summarize the important expression, localization, and function of ion channels in normal exocrine pancreatic tissue and how they are involved in PDAC progression and development. As ion channels are suggested to be potential targets of treatment they are furthermore suggested to be biomarkers of different cancers. Therefore, we describe the importance of ion channels in PDAC as markers of diagnosis and clinical factors.
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spelling pubmed-75962762020-11-10 Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma Schnipper, Julie Dhennin-Duthille, Isabelle Ahidouch, Ahmed Ouadid-Ahidouch, Halima Front Pharmacol Pharmacology Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer-related deaths in United States and Europe. It is predicted that PDAC will become the second leading cause of cancer-related deaths during the next decades. The development of PDAC is not well understood, however, studies have shown that dysregulated exocrine pancreatic fluid secretion can contribute to pathologies of exocrine pancreas, including PDAC. The major roles of healthy exocrine pancreatic tissue are secretion of enzymes and bicarbonate rich fluid, where ion channels participate to fine-tune these biological processes. It is well known that ion channels located in the plasma membrane regulate multiple cellular functions and are involved in the communication between extracellular events and intracellular signaling pathways and can function as signal transducers themselves. Hereby, they contribute to maintain resting membrane potential, electrical signaling in excitable cells, and ion homeostasis. Despite their contribution to basic cellular processes, ion channels are also involved in the malignant transformation from a normal to a malignant phenotype. Aberrant expression and activity of ion channels have an impact on essentially all hallmarks of cancer defined as; uncontrolled proliferation, evasion of apoptosis, sustained angiogenesis and promotion of invasion and migration. Research indicates that certain ion channels are involved in the aberrant tumor growth and metastatic processes of PDAC. The purpose of this review is to summarize the important expression, localization, and function of ion channels in normal exocrine pancreatic tissue and how they are involved in PDAC progression and development. As ion channels are suggested to be potential targets of treatment they are furthermore suggested to be biomarkers of different cancers. Therefore, we describe the importance of ion channels in PDAC as markers of diagnosis and clinical factors. Frontiers Media S.A. 2020-10-16 /pmc/articles/PMC7596276/ /pubmed/33178018 http://dx.doi.org/10.3389/fphar.2020.568993 Text en Copyright © 2020 Schnipper, Dhennin-Duthille, Ahidouch and Ouadid-Ahidouch http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Schnipper, Julie
Dhennin-Duthille, Isabelle
Ahidouch, Ahmed
Ouadid-Ahidouch, Halima
Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma
title Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma
title_full Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma
title_fullStr Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma
title_full_unstemmed Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma
title_short Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma
title_sort ion channel signature in healthy pancreas and pancreatic ductal adenocarcinoma
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596276/
https://www.ncbi.nlm.nih.gov/pubmed/33178018
http://dx.doi.org/10.3389/fphar.2020.568993
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