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Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations

OBJECTIVE: The brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) polymorphism is suggested to be associated with the pathophysiology of anxiety disorders, including panic disorder (PD). Although the fronto-limbic white matter (WM) microstructures have been investigated, the corpus callosum...

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Autores principales: Kim, Hyun-Ju, Bang, Minji, Lee, Kang Soo, Choi, Tai Kiu, Park, Chun Il, Lee, Sang-Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596279/
https://www.ncbi.nlm.nih.gov/pubmed/33017888
http://dx.doi.org/10.30773/pi.2020.0186
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author Kim, Hyun-Ju
Bang, Minji
Lee, Kang Soo
Choi, Tai Kiu
Park, Chun Il
Lee, Sang-Hyuk
author_facet Kim, Hyun-Ju
Bang, Minji
Lee, Kang Soo
Choi, Tai Kiu
Park, Chun Il
Lee, Sang-Hyuk
author_sort Kim, Hyun-Ju
collection PubMed
description OBJECTIVE: The brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) polymorphism is suggested to be associated with the pathophysiology of anxiety disorders, including panic disorder (PD). Although the fronto-limbic white matter (WM) microstructures have been investigated, the corpus callosum (CC) has not yet been studied regarding its relationship with BDNF Val66Met polymorphism in PD. METHODS: Ninety-five PD patients were enrolled. The Neuroticism, the Anxiety Sensitivity Inventory-Revised, Panic Disorder Severity Scale, and Beck Depression Inventory-II (BDI-II) were administered. Voxel-wise statistical analysis of diffusion tensor imaging data was performed within the CC regions using Tract-Based Spatial Statistics. RESULTS: The GG genotype in BDNF Val66Met polymorphism has significantly higher fractional anisotropy (FA) values of the body and splenium of the CC, neuroticism and depressive symptom scale scores than the non-GG genotype in PD. The FA values of the body of the CC in the two groups were significantly different independent of age, sex, neuroticism, and BDI-II. CONCLUSION: Our findings demonstrate that the BDNF Val66Met polymorphism is associated with WM connectivity of the body and splenium of the CC, and may be related to neuroticism and depressive symptoms in PD. Additionally, the CC connectivity according to BDNF polymorphism may play a role in the pathophysiology of PD.
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spelling pubmed-75962792020-11-03 Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations Kim, Hyun-Ju Bang, Minji Lee, Kang Soo Choi, Tai Kiu Park, Chun Il Lee, Sang-Hyuk Psychiatry Investig Original Article OBJECTIVE: The brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) polymorphism is suggested to be associated with the pathophysiology of anxiety disorders, including panic disorder (PD). Although the fronto-limbic white matter (WM) microstructures have been investigated, the corpus callosum (CC) has not yet been studied regarding its relationship with BDNF Val66Met polymorphism in PD. METHODS: Ninety-five PD patients were enrolled. The Neuroticism, the Anxiety Sensitivity Inventory-Revised, Panic Disorder Severity Scale, and Beck Depression Inventory-II (BDI-II) were administered. Voxel-wise statistical analysis of diffusion tensor imaging data was performed within the CC regions using Tract-Based Spatial Statistics. RESULTS: The GG genotype in BDNF Val66Met polymorphism has significantly higher fractional anisotropy (FA) values of the body and splenium of the CC, neuroticism and depressive symptom scale scores than the non-GG genotype in PD. The FA values of the body of the CC in the two groups were significantly different independent of age, sex, neuroticism, and BDI-II. CONCLUSION: Our findings demonstrate that the BDNF Val66Met polymorphism is associated with WM connectivity of the body and splenium of the CC, and may be related to neuroticism and depressive symptoms in PD. Additionally, the CC connectivity according to BDNF polymorphism may play a role in the pathophysiology of PD. Korean Neuropsychiatric Association 2020-10 2020-10-07 /pmc/articles/PMC7596279/ /pubmed/33017888 http://dx.doi.org/10.30773/pi.2020.0186 Text en Copyright © 2020 Korean Neuropsychiatric Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Hyun-Ju
Bang, Minji
Lee, Kang Soo
Choi, Tai Kiu
Park, Chun Il
Lee, Sang-Hyuk
Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations
title Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations
title_full Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations
title_fullStr Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations
title_full_unstemmed Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations
title_short Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations
title_sort effects of bdnf val66met polymorphism on white matter microalterations of the corpus callosum in patients with panic disorder in korean populations
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596279/
https://www.ncbi.nlm.nih.gov/pubmed/33017888
http://dx.doi.org/10.30773/pi.2020.0186
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